Acvr2b - activin A receptor type 2B Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25366

About Acvr2b

Primary_assembly 8: 119,138,812-119,170,458 forward strand.mRatBN7.2:CM026981.1

This gene has 2 transcripts (splice variants), 259 orthologues, 11 paralogues and is associated with 5 phenotypes. Biased expression in Muscle (RPKM 28.7), Kidney (RPKM 21.8) and 9 other tissues.

Summary

Enables activin binding activity and inhibin binding activity. Involved in adrenal gland development. Predicted to be located in cytoplasm. Predicted to be part of activin receptor complex. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in visceral heterotaxy. Orthologous to human ACVR2B (Activin A receptor type 2B). [provided by Alliance of Genome Resources, Apr 2022]

Acvr2b Products (1)

mRNA Protein Name
NM_031554.1 NP_113742.1 activin receptor type-2B precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables activin binding IDA
IDA: Inferred from direct assay
12385827 RGD
enables inhibin binding IDA
IDA: Inferred from direct assay
12385827 RGD
Biological Process GO Annotation Evidence References Source
involved in adrenal gland development IEP
IEP: Inferred from expression pattern
12844345 RGD
involved in response to activity IEP
IEP: Inferred from expression pattern
22332899 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Acvr2b Protein Structure

Activin_recp

Activin_recp: pfam01064 (49 - 118)

STKc_ACVR2b

STKc_ACVR2b: cd14140 (226 - 516)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 545 a.a.
Protein Preferred Names Protein Names

activin receptor type-2B

  • ACTR-IIB

  • ActRIIB type II activin receptor B

  • Activine receptor 2b (transmembrane serine kinase)

  • activin A receptor, type IIB

  • activin receptor IIB

  • activin receptor type IIB

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99355 Bimagrumab Inhibitor 99.31% Phase 3

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-185430 HM-279 Inhibitor / Unkown
HY-W1142089 ActRIIB-IN-2 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Acvr2b NCBI NCBI:93