EML3 - EMAP like 3 Gene

Also Known as ELP95; EMAP3; EMAP95

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 256364

About EML3

Cytogenetic location: 11q12.3 Genomic coordinates (GRCh38): 11:62,602,218-62,612,775 (from NCBI)

This gene has 18 transcripts (splice variants), 194 orthologues and 9 paralogues. Ubiquitous expression in spleen (RPKM 13.3), fat (RPKM 13.0) and 25 other tissues.

Summary

Predicted to enable microtubule binding activity. Involved in mitotic metaphase plate congression and regulation of mitotic spindle assembly. Located in several cellular components, including midbody; mitotic spindle microtubule; and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

EML3 Products (4)

mRNA Protein Name
NM_001300793.2 NP_001287722.1 echinoderm microtubule-associated protein-like 3 isoform 1
NM_001300794.2 NP_001287723.1 echinoderm microtubule-associated protein-like 3 isoform 2
NM_001411016.1 NP_001397945.1 echinoderm microtubule-associated protein-like 3 isoform 4
NM_153265.3 NP_694997.2 echinoderm microtubule-associated protein-like 3 isoform 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25740311 GOA
Biological Process GO Annotation Evidence References Source
involved in mitotic metaphase chromosome alignment IMP
IMP: Inferred from mutant phenotype
18445686 GOA
involved in regulation of mitotic spindle assembly IMP
IMP: Inferred from mutant phenotype
30723163 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
18445686 GOA
located in microtubule cytoskeleton IDA
IDA: Inferred from direct assay
18445686 GOA
located in midbody IDA
IDA: Inferred from direct assay
18445686 GOA
located in mitotic spindle microtubule IDA
IDA: Inferred from direct assay
30723163 GOA
located in nucleus IDA
IDA: Inferred from direct assay
18445686 GOA
located in spindle IDA
IDA: Inferred from direct assay
18445686 GOA
located in spindle microtubule IDA
IDA: Inferred from direct assay
18445686 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EML3 Protein Structure

HELP

HELP: HELP motif (215 - 284)

WD40

WD40: WD domain, G-beta repeat (299 - 323)

WD40

WD40: WD domain, G-beta repeat (592 - 625)

WD40

WD40: WD domain, G-beta repeat (684 - 708)

WD40

WD40: WD domain, G-beta repeat (724 - 754)

WD40

WD40: WD domain, G-beta repeat (833 - 867)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 896 a.a.
Protein Preferred Names Protein Names

echinoderm microtubule-associated protein-like 3

  • EMAP-3

EML3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
EML3 Q32P44 DDIT4L Homo sapiens Q96D03
Validated Y2H
32296183
Intra
EML3 Q32P44 DDIT4L Homo sapiens Q96D03
Y2H Array
32296183
Intra
EML3 Q32P44 DDIT4L Homo sapiens Q96D03
Y2H Prey Pooling
32296183
Intra
EML3 Q32P44 ATXN1 Homo sapiens P54253
Y2H Array
32296183
Intra
EML3 Q32P44 ATXN1 Homo sapiens P54253
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04355 EML3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta EML3 VGNC VGNC:72120
Bos taurus EML3 VGNC VGNC:28477
Mus musculus EML3 MGD MGI:2387612
Felis catus EML3 VGNC VGNC:61850
Canis familiaris EML3 VGNC VGNC:40348
Rattus norvegicus EML3 RGD RGD:7630023
Others EML3 NCBI