Mc5r - melanocortin 5 receptor Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25726

About Mc5r

Primary_assembly 18: 61,915,188-61,920,229 forward strand.mRatBN7.2:CM026991.1

This gene has 1 transcript (splice variant), 183 orthologues, 18 paralogues and is associated with 3 phenotypes.

Summary

Enables hormone binding activity and Melanocortin Receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and regulation of metabolic process. Predicted to be integral component of membrane. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human MC5R (melanocortin 5 receptor). [provided by Alliance of Genome Resources, Apr 2022]

Mc5r Products (1)

mRNA Protein Name
NM_013182.3 NP_037314.1 melanocortin receptor 5

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables hormone binding IDA
IDA: Inferred from direct assay
8179577 RGD
enables hormone binding IMP
IMP: Inferred from mutant phenotype
16454799 RGD
enables melanocortin receptor activity IDA
IDA: Inferred from direct assay
8179577 RGD
enables melanocortin receptor activity IMP
IMP: Inferred from mutant phenotype
16454799 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Mc5r Protein Structure

7tm_GPCRs

7tm_GPCRs: cl28897 (36 - 305)

7tm_GPCRs

7tm_GPCRs: cd14964 (38 - 62)

7tm_GPCRs

7tm_GPCRs: cd14964 (71 - 93)

7tm_GPCRs

7tm_GPCRs: cd14964 (115 - 137)

7tm_GPCRs

7tm_GPCRs: cd14964 (160 - 176)

7tm_GPCRs

7tm_GPCRs: cd14964 (182 - 205)

7tm_GPCRs

7tm_GPCRs: cd14964 (236 - 258)

7tm_GPCRs

7tm_GPCRs: cd14964 (273 - 298)

  • 0
  • 100
  • 200
  • 300
  • 325 a.a.
Protein Preferred Names Protein Names

melanocortin receptor 5

  • MC5-R

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-107139 JNJ-10229570 Antagonist 98.0% Phase 2

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P0227 SHU 9119 99.83% Unkown
HY-P0097A Nonapeptide-1 acetate salt Antagonist 95.58% Unkown
HY-P0097 Nonapeptide-1 Antagonist 98.74% Unkown
HY-19870C Setmelanotide monoacetate Agonist 99.81% Unkown
HY-P11469 PG-901 Modulator 99.35% Unkown
HY-P4665 Ac-c[Cys-Glu-His-d-Phe-Arg-Trp-d-Cys]-Pro-Pro-Lys-Asp-NH2 Antagonist 98.14% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mc5r NCBI NCBI:4161