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BRI3 - brain protein I3 Gene

Also Known as I3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 25798

About BRI3

Cytogenetic location: 7q21.3 Genomic coordinates (GRCh38): 7:98,281,686-98,323,430 (from NCBI)

This gene has 7 transcripts (splice variants) and 187 orthologues. Ubiquitous expression in lung (RPKM 12.8), stomach (RPKM 11.3) and 25 other tissues.

Summary

Enables identical protein binding activity. Predicted to be located in azurophil granule membrane and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

BRI3 Products (2)

mRNA	Protein	Name
NM_001159491.2	NP_001152963.1	brain protein I3 isoform b
NM_015379.5	NP_056194.1	brain protein I3 isoform a

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IDA IDA: Inferred from direct assay	15606899	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11860200	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BRI3 Protein Structure

DUF2367

0
100
125 a.a.

Protein Preferred Names	Protein Names
brain protein I3	pRGR2

BRI3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	BRI3	O95415	ABHD16A	Homo sapiens	O95870	Validated Y2H	32296183
Intra	BRI3	O95415	BRI3BP	Homo sapiens	Q8WY22	Anti Tag CoIP	30983867
Intra	BRI3	O95415	BRI3BP	Homo sapiens	Q8WY22	Y2H	11860200
Intra	BRI3	O95415	MGAT1	Homo sapiens	P26572	Confocal	30983867
Intra	BRI3	O95415	MGAT1	Homo sapiens	P26572	Anti Tag CoIP	30983867
Intra	BRI3	O95415	MGAT1	Homo sapiens	P26572	Y2H	30983867
Intra	BRI3	O95415	MALL	Homo sapiens	Q13021	Validated Y2H	32296183
Intra	BRI3	O95415	IFITM3	Homo sapiens	Q01628	Anti Tag CoIP	30983867
Intra	BRI3	O95415	IFITM3	Homo sapiens	Q01628	Confocal	30983867
Intra	BRI3	O95415	IFITM3	Homo sapiens	Q01628	Y2H	30983867

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Developmental And Epileptic Encephalopathy 45	DEE45 Epileptic Encephalopathy, Early Infantile, 45 Eiee45 Developmental And Epileptic Encephalopathy, 45 Early Infantile Epileptic Encephalopathy 45
Developmental And Epileptic Encephalopathy 46	DEE46 Epileptic Encephalopathy, Early Infantile, 46 Eiee46 Developmental And Epileptic Encephalopathy, 46 Early Infantile Epileptic Encephalopathy 46
Developmental And Epileptic Encephalopathy 49	DEE49 Epileptic Encephalopathy, Early Infantile, 49 Eiee49 Developmental And Epileptic Encephalopathy, 49 Early Infantile Epileptic Encephalopathy 49
Developmental And Epileptic Encephalopathy 34	DEE34 Epileptic Encephalopathy, Early Infantile, 34 Eiee34 Developmental And Epileptic Encephalopathy, 34 Early Infantile Epileptic Encephalopathy 34
Developmental And Epileptic Encephalopathy 42	DEE42 Epileptic Encephalopathy, Early Infantile, 42 Eiee42 Developmental And Epileptic Encephalopathy, 42 Early Infantile Epileptic Encephalopathy 42 Encephalopathy, Epileptic, Early Infantile, Type 42
Developmental And Epileptic Encephalopathy 4	DEE4 Epileptic Encephalopathy, Early Infantile, 4 Eiee4 Early Infantile Epileptic Encephalopathy 4 Stxbp1-Related Early-Onset Encephalopathy Early Myoclonic Encephalopathy Developmental And Epileptic Encephalopathy, 4 Stxbp1 Disorders Stxbp1 Encephalopathy Developmental And Epileptic Encephalopathy, Type 4 Early-Infantile Epileptic Encephalopathy 4 Stxbp1 Encephalopathy With Epilepsy Stxbp1 Epileptic Encephalopathy Stxbp1-Related Developmental And Epileptic Encephalopathy Stxbp1-Related Epileptic Encephalopathy Eme Neonatal Epilepsy With Suppression-Burst Pattern Encephalopathy, Epileptic, Early Infantile, Type 4
Retinitis Pigmentosa 3	RP3 Retinitis Pigmentosa 15 Rp15 Choroidoretinal Degeneration With Retinal Reflex In Heterozygous Women Cone-Rod Degeneration, X-Linked Retinitis Pigmentosa Type 15 X-Linked Cone-Rod Degeneration X-Linked Retinitis Pigmentosa 3 Xlrp3 Xlrp-3 Retinitis Pigmentosa-3 Retinitis Pigmentosa, Type 3

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01618	BRI3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS01619	BRI3BP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS06985	ITM2C Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	BRI3	VGNC	VGNC:26564
Canis familiaris	BRI3	VGNC	VGNC:38525
Mus musculus	BRI3	MGD	MGI:1933174
Rattus norvegicus	BRI3	RGD	RGD:1309187
Macaca mulatta	BRI3	VGNC	VGNC:70283
Felis catus	BRI3	VGNC	VGNC:107742
Others	BRI3	NCBI