DNAJB5 - DnaJ heat shock protein family (Hsp40) member B5 Gene

Also Known as Hsc40

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 25822

About DNAJB5

Cytogenetic location: 9p13.3 Genomic coordinates (GRCh38): 9:34,989,745-34,998,900 (from NCBI)

This gene has 12 transcripts (splice variants), 281 orthologues and 11 paralogues. Broad expression in heart (RPKM 17.5), brain (RPKM 13.1) and 21 other tissues.

Summary

This gene encodes a member of the DNAJ heat shock protein 40 family of co-chaperone proteins. The encoded protein contains an N-terminal DNAJ domain and a C-terminal substrate binding domain but lacks the cysteine-rich domain found in Other DNAJ family members. In mice, a multi-protein complex containing this protein, thioredoxin 1, and histone deacetylase 4, serves as a master negative regulator of cardiac hypertrophy. [provided by RefSeq, Mar 2017]

DNAJB5 Products (6)

mRNA	Protein	Name
NM_001135004.3	NP_001128476.3	dnaJ homolog subfamily B member 5 isoform 2
NM_001135005.3	NP_001128477.1	dnaJ homolog subfamily B member 5 isoform 1
NM_001349723.3	NP_001336652.1	dnaJ homolog subfamily B member 5 isoform 1
NM_001349724.2	NP_001336653.1	dnaJ homolog subfamily B member 5 isoform 3
NM_001349725.2	NP_001336654.2	dnaJ homolog subfamily B member 5 isoform 2
NM_012266.6	NP_036398.3	dnaJ homolog subfamily B member 5 isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18457437	GOA
enables protein-folding chaperone binding	IPI IPI: Inferred from physical interaction	21231916	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in response to unfolded protein	IEP IEP: Inferred from expression pattern	10570961	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytosol	IDA IDA: Inferred from direct assay	21231916	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DNAJB5 Protein Structure

DnaJ

DnaJ_C

0
100
200
300
348 a.a.

Protein Preferred Names	Protein Names
dnaJ homolog subfamily B member 5	DnaJ (Hsp40) homolog, subfamily B, member 5

DNAJB5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	DNAJB5	O75953	TTN	Homo sapiens	Q8WZ42	Y2H Fragment Pooling	23414517
Intra	DNAJB5	O75953	CACNA1A	Homo sapiens	O00555	Pull Down	21078624

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Skeletal Muscle Disease
Peripheral Nervous System Disease	Peripheral Neuropathy Peripheral Nerve Disease Peripheral Nerve Disorders Neuropathy, Peripheral Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation
Fatal Infantile Hypertonic Myofibrillar Myopathy
Borjeson-Forssman-Lehmann Syndrome	BFLS Borj Borjeson Syndrome Mrxsbfl Intellectual Deficiency-Epilepsy-Endocrine Disorders Syndrome Intellectual Disability-Epilepsy-Endocrine Disorders Syndrome Mental Retardation, X-Linked, Syndromic, Borjeson-Forssman-Lehmann Type Mental Retardation, Epilepsy, And Endocrine Disorders Mental Retardation, Epilepsy, And Endocrine Disorder Syndromic X-Linked Mental Retardation Borjeson-Forssman-Lehmann Type Mental Deficiency, Epilepsy And Endocrine Disorders Boerjeson-Forssman-Lehmann Syndrome Borjeson-Forssman Syndrome Mental Deficiency-Epilepsy- Endocrine Disorders

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03868	DNAJB5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	DNAJB5	VGNC	VGNC:51709
Felis catus	DNAJB5	VGNC	VGNC:102921
Rattus norvegicus	DNAJB5	RGD	RGD:1307453
Macaca mulatta	DNAJB5	VGNC	VGNC:103256
Mus musculus	DNAJB5	MGD	MGI:1930018
Bos taurus	DNAJB5	VGNC	VGNC:56945
Others	DNAJB5	NCBI