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ASF1A - anti-silencing function 1A histone chaperone Gene

Also Known as CIA; CGI-98; HSPC146

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 25842

About ASF1A

Cytogenetic location: 6q22.31 Genomic coordinates (GRCh38): 6:118,894,152-118,909,171 (from NCBI)

This gene has 2 transcripts (splice variants), 145 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 9.8), brain (RPKM 9.4) and 25 other tissues.

Summary

This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The protein is a key component of a histone donor complex that functions in nucleosome assembly. It interacts with histones H3 and H4, and functions together with a chromatin assembly factor during DNA replication and repair. [provided by RefSeq, Jul 2008]

ASF1A Products (1)

mRNA	Protein	Name
NM_014034.3	NP_054753.1	histone chaperone ASF1A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables histone binding	IDA IDA: Inferred from direct assay	10759893	GOA
enables histone chaperone activity	IDA IDA: Inferred from direct assay	10759893	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within DNA repair	IDA IDA: Inferred from direct assay	11897662	GOA
involved in DNA repair-dependent chromatin remodeling	IDA IDA: Inferred from direct assay	29478807	GOA
acts upstream of or within nucleosome assembly	IDA IDA: Inferred from direct assay	11897662	GOA
involved in nucleosome assembly	IDA IDA: Inferred from direct assay	14718166	GOA
involved in replication fork processing	IDA IDA: Inferred from direct assay	29478807	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in chromatin	IDA IDA: Inferred from direct assay	14718166	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	14718166	GOA
is active in site of double-strand break	IDA IDA: Inferred from direct assay	29478807	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ASF1A Protein Structure

ASF1_hist_chap

0
100
204 a.a.

Protein Preferred Names	Protein Names
histone chaperone ASF1A	ASF1 anti-silencing function 1 homolog A

ASF1A Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ASF1A	Q9Y294	TLK2	Homo sapiens	Q86UE8	TAP	24981860
Intra	ASF1A	Q9Y294	TLK2	Homo sapiens	Q86UE8	Anti Tag CoIP	33961781
Intra	ASF1A	Q9Y294	TLK2	Homo sapiens	Q86UE8	Protein Kinase Assay	33323470
Intra	ASF1A	Q9Y294	CHAF1B	Homo sapiens	Q13112	Pull Down	16980972
Intra	ASF1A	Q9Y294	CHAF1B	Homo sapiens	Q13112	TAP	24981860
Intra	ASF1A	Q9Y294	CHAF1B	Homo sapiens	Q13112	Anti Tag CoIP	16980972
Intra	ASF1A	Q9Y294	PRR3	Homo sapiens	P79522	Validated Y2H	25416956
Intra	ASF1A	Q9Y294	H4C16	Homo sapiens	P62805	Anti Tag CoIP	28514442
Intra	ASF1A	Q9Y294	H4C16	Homo sapiens	P62805	Anti Tag CoIP	33961781
Intra	ASF1A	Q9Y294	H4C16	Homo sapiens	P62805	Y2H Prey Pooling	25416956
Intra	ASF1A	Q9Y294	H4C16	Homo sapiens	P62805	Light Scattering	26167883
Intra	ASF1A	Q9Y294	H4C16	Homo sapiens	P62805	GMS	26167883
Intra	ASF1A	Q9Y294	H4C16	Homo sapiens	P62805	Pull Down	26167883
Intra	ASF1A	Q9Y294	H4C16	Homo sapiens	P62805	TAP	24981860
Intra	ASF1A	Q9Y294	H4C16	Homo sapiens	P62805	Pull Down	23075851
Intra	ASF1A	Q9Y294	HIRA	Homo sapiens	P54198	TAP	24981860
Intra	ASF1A	Q9Y294	HIRA	Homo sapiens	P54198	Anti Tag CoIP	33961781
Intra	ASF1A	Q9Y294	HIRA	Homo sapiens	P54198	Anti Tag CoIP	26496610
Intra	ASF1A	Q9Y294	HIRA	Homo sapiens	P54198	Anti Bait CoIP	19029251
Intra	ASF1A	Q9Y294	MCM2	Homo sapiens	P49736	GMS	26167883
Intra	ASF1A	Q9Y294	MCM2	Homo sapiens	P49736	Pull Down	26167883
Intra	ASF1A	Q9Y294	MCM2	Homo sapiens	P49736	Anti Tag CoIP	28514442
Intra	ASF1A	Q9Y294	MCM2	Homo sapiens	P49736	TAP	24981860
Intra	ASF1A	Q9Y294	MCM2	Homo sapiens	P49736	Light Scattering	26167883
Intra	ASF1A	Q9Y294	TLK1	Homo sapiens	Q9UKI8	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ASF1A Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70119	Histone chaperone ASF1A/ASF1A Protein, Human (T7-His)	Q9Y294 (M1-M204)	≥ 95%, as determined by reducing SDS-PAGE.

ASF1A Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P84887	ASF1A Antibody (YA4584)	FC, ELISA	Human
HY-P84887A	ASF1A Antibody (YA4584)(PBS only)	FC, ELISA	Human

Related Diseases

Diseases	Alias
Cataract 34, Multiple Types	Cataract, Autosomal Recessive Congenital 3 Cataract 34 Multiple Types CTRCT34 Catc3 Cataract 34, Multiple Types, With Or Without Microcornea Autosomal Recessive Congenital Cataract 3 Cataract 34 Multiple Types With Or Without Microcornea Cataract, Multiple Types, Type 34
Alpha-Thalassemia	Alpha Thalassemia Alpha Thalassaemia Alpha Plus Thalassemia Thalassemia, Alpha- Thalassemias, Alpha- A-Thalassemia Α-Thalassemia A-THAL Thalassemia Alpha Thalassaemia Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01083	ASF1A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18508	Asf1a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24990	Asf1a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ASF1A	RGD	RGD:1311941
Macaca mulatta	ASF1A	VGNC	VGNC:69871
Mus musculus	ASF1A	MGD	MGI:1913653
Felis catus	ASF1A	VGNC	VGNC:102383
Bos taurus	ASF1A	VGNC	VGNC:50604
Canis familiaris	ASF1A	VGNC	VGNC:50621
Others	ASF1A	NCBI