IL4I1 - interleukin 4 induced 1 Gene

Also Known as LAO; FIG1; LAAO; hIL4I1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 259307

About IL4I1

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:49,889,654-49,929,504 (from NCBI)

This gene has 8 transcripts (splice variants), 325 orthologues and 7 paralogues. Broad expression in testis (RPKM 12.4), liver (RPKM 8.9) and 22 other tissues.

Summary

This gene encodes a secreted L-amino acid oxidase protein which primarily catabolizes L-phenylalanine and, to a lesser extent, L-arginine. The expression of this gene is induced by the cytokine interleukin 4 in B cells. This gene is also expressed in macrophages and dendritic cells. This protein may play a role immune system escape as it is expressed in tumor-associated macrophages and suppresses T-cell responses. This protein also contains domains thought to be involved in the binding of flavin adenine dinucleotide (FAD) cofactor. Multiple transcript variants encoding different isoforms have been found for this gene. Some transcripts of this gene share a promoter and exons of the 5' UTR with the overlapping NUP62 gene. [provided by RefSeq, Jul 2020]

IL4I1 Products (5)

mRNA	Protein	Name
NM_001258017.2	NP_001244946.1	L-amino-acid oxidase isoform 2 precursor
NM_001258018.2	NP_001244947.1	L-amino-acid oxidase isoform 2 precursor
NM_001385639.1	NP_001372568.1	L-amino-acid oxidase isoform 3 precursor
NM_152899.2	NP_690863.1	L-amino-acid oxidase isoform 1 precursor
NM_172374.3	NP_758962.1	L-amino-acid oxidase isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables L-amino-acid oxidase activity	IDA IDA: Inferred from direct assay	17356132	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32814053	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in L-phenylalanine catabolic process	IDA IDA: Inferred from direct assay	17356132	GOA
involved in negative regulation of T cell activation	IDA IDA: Inferred from direct assay	28891065	GOA
involved in negative regulation of T cell mediated immune response to tumor cell	IDA IDA: Inferred from direct assay	32818467	GOA
involved in negative regulation of T cell proliferation	IMP IMP: Inferred from mutant phenotype	17356132	GOA
involved in positive regulation of regulatory T cell differentiation	IDA IDA: Inferred from direct assay	25778793	GOA
acts upstream of positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	32818467	GOA
involved in regulation of adaptive immune response	IDA IDA: Inferred from direct assay	17356132	GOA
involved in tryptophan catabolic process	IDA IDA: Inferred from direct assay	17356132	GOA
involved in tryptophan catabolic process to indole-3-acetate	IDA IDA: Inferred from direct assay	32818467	GOA
involved in tyrosine catabolic process	IDA IDA: Inferred from direct assay	17356132	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in acrosomal vesicle	IDA IDA: Inferred from direct assay	25767141	GOA
located in extracellular region	IDA IDA: Inferred from direct assay	17356132	GOA
located in immunological synapse	IDA IDA: Inferred from direct assay	28891065	GOA
located in sperm midpiece	IDA IDA: Inferred from direct assay	25767141	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IL4I1 Protein Structure

Amino_oxidase

0
100
200
300
400
500
567 a.a.

Protein Preferred Names	Protein Names
L-amino-acid oxidase	Fig-1 protein

IL4I1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	IL4I1	Q96RQ9	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	IL4I1	Q96RQ9	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	IL4I1	Q96RQ9	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	IL4I1	Q96RQ9	OPTN	Homo sapiens	Q96CV9	Y2H Array	32814053
Intra	IL4I1	Q96RQ9	OPTN	Homo sapiens	Q96CV9	Validated Y2H	32814053
Intra	IL4I1	Q96RQ9	OPTN	Homo sapiens	Q96CV9	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

IL4I1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81480	IL-4I1/LAO Antibody (YA1225)	IHC-P	Human
HY-P81480A	IL-4I1/LAO Antibody (YA1225)(PBS only)	IHC-P	Human

Related Diseases

Diseases	Alias
Striatonigral Degeneration, Infantile	Infantile Bilateral Striatal Necrosis Ibsn SNDI Striatonigral Degeneration Infantile Infantile Striatonigral Degeneration Bilateral Striatal Necrosis, Infantile Striatal Degeneration, Familial Striatal Degeneration Familial Infantile Striatonigral Necrosis Familial Striatal Degeneration
Primary Mediastinal Large B-Cell Lymphoma	Mediastinal Large B-Cell Lymphoma Large Cell Lymphoma Of The Mediastinum Med-Dlbcl Mediastinal Diffuse Large-Cell Lymphoma With Sclerosis Primary Mediastinal Clear Cell Lymphoma Of B-Cell Type Mediastinal Large B-Cell Lymphoma
B-Cell Lymphoma	Lymphoma, B-Cell B-Cell Lymphomas B-Cell Lymphocytic Neoplasm Lymphoma B-Cell B-Cell Lymphoma Nos
Gas Gangrene	Myonecrosis Gas Bacillus Infection Gas Gangrene Due To Clostridia Clostridial Myonecrosis Clostridial Cellulitis
Diffuse Large B-Cell Lymphoma	Dlbcl Diffuse Large B-Cell Lymphoma, Not Otherwise Specified Large B-Cell Diffuse Lymphoma Lymphoma, Large B-Cell, Diffuse Dlbcl - [Diffuse Large B-Cell Lymphoma] Diffuse Large Beta Cell Lymphoma
Patent Foramen Ovale	Atrial Septal Defect Within Oval Fossa Foramen Ovale Patent Ostium Secundum Atrial Septal Defect Atrial Septal Defect, Ostium Secundum Type Foramen Ovale, Patent Defect, Patent Or Persistent, Ostium Secundum Ostium Secundum Type Atrial Septal Defect Persistent Ostium Secundum Asd Ostium Secundum Type Ostium Secundum Asd Osasd Asd, Ostium Secundum Type Pfo - [Patent Foramen Ovale] Open Foramen Ovale Open Oval Foramen Persistent Foramen Ovale Secundum Atrial Septal Defect

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-174262	IL4I1-IN-1	Inhibitor	99.95%	Unkown
HY-184554	ZY-MY-111	Inhibitor	/	Unkown
HY-RS06768	IL4I1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17465	Il4i1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23923	Il4i1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	IL4I1	VGNC	VGNC:41988
Felis catus	IL4I1	VGNC	VGNC:62914
Mus musculus	IL4I1	MGD	MGI:109552
Macaca mulatta	IL4I1	VGNC	VGNC:73625
Rattus norvegicus	IL4I1	RGD	RGD:1304831
Bos taurus	IL4I1	VGNC	VGNC:30162
Others	IL4I1	NCBI