AOC1 - amine oxidase copper containing 1 Gene

Also Known as ABP; DAO; KAO; ABP1; DAO1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 26

About AOC1

Cytogenetic location: 7q36.1 Genomic coordinates (GRCh38): 7:150,852,120-150,861,504 (from NCBI)

This gene has 7 transcripts (splice variants), 233 orthologues and 2 paralogues. Biased expression in placenta (RPKM 229.3), kidney (RPKM 118.3) and 3 other tissues.

Summary

This gene encodes a metal-binding membrane glycoprotein that oxidatively deaminates putrescine, histamine, and related compounds. The encoded protein is inhibited by amiloride, a diuretic that acts by closing epithelial sodium ion channels. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013]

AOC1 Products (2)

mRNA Protein Name
NM_001091.4 NP_001082.2 amiloride-sensitive amine oxidase [copper-containing] isoform 2 precursor
NM_001272072.2 NP_001259001.1 amiloride-sensitive amine oxidase [copper-containing] isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium ion binding IDA
IDA: Inferred from direct assay
12072962 GOA
enables copper ion binding IDA
IDA: Inferred from direct assay
12072962 GOA
enables diamine oxidase activity IDA
IDA: Inferred from direct assay
8144586 GOA
enables heparin binding IDA
IDA: Inferred from direct assay
19764817 GOA
enables histamine oxidase activity IDA
IDA: Inferred from direct assay
12072962 GOA
enables primary methylamine oxidase activity IDA
IDA: Inferred from direct assay
8144586 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables protein homodimerization activity IPI
IPI: Inferred from physical interaction
19764817 GOA
enables putrescine oxidase activity IDA
IDA: Inferred from direct assay
7626074 GOA
Biological Process GO Annotation Evidence References Source
involved in putrescine metabolic process IMP
IMP: Inferred from mutant phenotype
8144586 GOA
Cellular Component GO Annotation Evidence References Source
located in extracellular exosome IDA
IDA: Inferred from direct assay
21082674 GOA
is active in extracellular space IDA
IDA: Inferred from direct assay
8144586 GOA
located in extracellular space IDA
IDA: Inferred from direct assay
9399025 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
2217167 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AOC1 Protein Structure

Cu_amine_oxidN2

Cu_amine_oxidN2: Copper amine oxidase, N2 domain (39 - 125)

Cu_amine_oxidN3

Cu_amine_oxidN3: Copper amine oxidase, N3 domain (141 - 240)

Cu_amine_oxid

Cu_amine_oxid: Copper amine oxidase, enzyme domain (302 - 713)

  • 0
  • 200
  • 400
  • 600
  • 751 a.a.
Protein Preferred Names Protein Names

amiloride-sensitive amine oxidase [copper-containing]

  • amiloride binding protein 1 (amine oxidase (copper-containing))

AOC1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
AOC1 P19801 KRTAP8-1 Homo sapiens Q8IUC2
Y2H Prey Pooling
32296183
Intra
AOC1 P19801 KRTAP8-1 Homo sapiens Q8IUC2
Y2H Array
32296183
Intra
AOC1 P19801 KRTAP8-1 Homo sapiens Q8IUC2
Validated Y2H
32296183
Intra
AOC1 P19801 TIAL1 Homo sapiens Q01085-2
Validated Y2H
32296183
Intra
AOC1 P19801 RBPMS2 Homo sapiens Q6ZRY4
Validated Y2H
32296183
Intra
AOC1 P19801 DAZAP2 Homo sapiens Q15038
Validated Y2H
32296183
Intra
AOC1 P19801 NTAQ1 Homo sapiens Q96HA8
Validated Y2H
32296183
Intra
AOC1 P19801 ZC3H10 Homo sapiens Q96K80
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant AOC1 Proteins

Cat. No. Product Name Accession Purity
HY-P7497 ABP1/AOC1 Protein, Human (HEK293, His) AAH14093.1 (E20-V751) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Food Allergy

  • Food Hypersensitivity

  • Food Allergies

  • Allergy Food

  • Food Allergen-Induced Hypersensitivity
Trimethoprim Allergy

  • Primsol Allergy

  • Proloprim Allergy

  • Tmp Allergy
Urticaria

  • Nettle Rash

  • Hives

  • Wheal

  • Urticaria Nos
Intestinal Disease

  • Intestinal Diseases
Short Bowel Syndrome

  • Short Gut Syndrome

  • Acquired Short Bowel Syndrome

  • Secondary Short Bowel Syndrome

  • Short Bowel Nos
Vernal Conjunctivitis

  • Conjunctivitis Vernal

  • Conjunctivitis, Vernal
Phlyctenulosis

  • Phlyctenular Keratoconjunctivitis

  • Strumous Ophthalmia
Rhinitis

  • Runny Nose
Autonomic Neuropathy

  • Diabetic Autonomic Neuropathy
Proctitis

  • Ulcerative Proctitis

  • Chronic Ulcerative Proctitis

  • Idiopathic Proctitis

  • Nonspecific Ulcerative Proctitis

  • Ulcerative Colitis Confined To Rectum

  • Ip - [Idiopathic Proctitis]

  • Chronic Ulcerative Proctitis Nos
Benign Ileal Neoplasm

  • Ileal Tumor

  • Ileal Neoplasms

  • Ileal Neoplasm
Acute Necrotizing Pancreatitis

  • Pancreatitis, Acute Necrotizing
Acute Vascular Insufficiency Of Intestine

  • Acute Gastrointestinal Tract Vascular Insuffic.

  • Acute Git Vascular Insuffic.

  • Acute Intestinal Ischemia

  • Acute Intestinal Vascular Insufficiency
Adermatoglyphia

  • ADERM

  • Immigration Delay Disease

  • Absence Of Fingerprints

  • Adg

  • Congenital Absence Of Fingerprints

  • Isolated Congenital Adermatoglyphia

  • Fingerprints, Absence Of

  • Skin Abnormalities
Allergic Disease

  • Hypersensitivity

  • Allergic Hypersensitivity Disease

  • Allergic Condition

  • Allergic Reaction

  • Allergic Disposition
Asthma

  • Chronic Obstructive Asthma

  • Asthma, Diminished Response To Antileukotriene Treatment In

  • Bronchial Hyperreactivity

  • Asthma, Susceptibility To

  • Asthma, Bronchial

  • Asthma, Protection Against

  • Asthma, Nocturnal, Susceptibility To

  • Nocturnal Asthma

  • Asthma-Related Traits

  • Asthma-Related Traits, Susceptibility To

  • Asthma, Nocturnal

  • Chronic Obstructive Asthma With Acute Exacerbation

  • Chronic Obstructive Asthma With Status Asthmaticus

  • Exercise Induced Asthma

  • Exercise-Induced Asthma

  • Bronchial Asthma

  • Asthma, Exercise-Induced

  • Idiosyncratic Asthma

  • Unspecified Asthma With Acute Exacerbation

  • Asthma, Unspecified, With Stated Status Asthmaticus

  • Status Asthmaticus Nos

  • Acute Severe Asthma

  • Acute Severe Bronchial Asthma

  • Status Asthma

  • Status Post Asthmaticus
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-143721 SSAO inhibitor-2 Inhibitor / Unkown
HY-143723 SSAO inhibitor-3 Inhibitor / Unkown
HY-RS00771 AOC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17364 Aoc1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23818 Aoc1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus AOC1 RGD RGD:61296
Macaca mulatta AOC1 VGNC VGNC:70033
Canis familiaris AOC1 VGNC VGNC:37947
Bos taurus AOC1 VGNC VGNC:25972
Felis catus AOC1 VGNC VGNC:68565
Mus musculus AOC1 MGD MGI:1923757
Others AOC1 NCBI