TRPC4AP - transient receptor potential cation channel subfamily C member 4 associated protein Gene

Also Known as TRUSS; TRRP4AP; PPP1R158; C20orf188

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 26133

About TRPC4AP

Cytogenetic location: 20q11.22 Genomic coordinates (GRCh38): 20:35,002,404-35,092,807 (from NCBI)

This gene has 2 transcripts (splice variants) and 232 orthologues. Ubiquitous expression in placenta (RPKM 20.6), spleen (RPKM 19.3) and 25 other tissues.

Summary

Enables Phosphatase binding activity and ubiquitin ligase-substrate adaptor activity. Involved in protein ubiquitination and ubiquitin-dependent protein catabolic process via the C-end degron rule pathway. Part of Cul4A-RING E3 ubiquitin Ligase complex. Is active in Cul4-RING E3 ubiquitin Ligase complex. [provided by Alliance of Genome Resources, Apr 2022]

TRPC4AP Products (2)

mRNA Protein Name
NM_015638.3 NP_056453.1 short transient receptor potential channel 4-associated protein isoform a
NM_199368.2 NP_955400.1 short transient receptor potential channel 4-associated protein isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables phosphatase binding IDA
IDA: Inferred from direct assay
19389623 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
19389623 GOA
enables ubiquitin-like ligase-substrate adaptor activity IDA
IDA: Inferred from direct assay
29779948 GOA
Biological Process GO Annotation Evidence References Source
involved in protein ubiquitination IDA
IDA: Inferred from direct assay
20551172 GOA
involved in ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
20551172 GOA
involved in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway IDA
IDA: Inferred from direct assay
29779948 GOA
Cellular Component GO Annotation Evidence References Source
part of Cul4-RING E3 ubiquitin ligase complex IDA
IDA: Inferred from direct assay
29779948 GOA
part of Cul4A-RING E3 ubiquitin ligase complex IDA
IDA: Inferred from direct assay
20551172 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRPC4AP Protein Structure

DUF3689

DUF3689: Protein of unknown function (DUF3689) (407 - 717)

  • 0
  • 200
  • 400
  • 600
  • 797 a.a.
Protein Preferred Names Protein Names

short transient receptor potential channel 4-associated protein

  • TNF-receptor ubiquitous scaffolding/signaling protein

TRPC4AP Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TRPC4AP Q8TEL6 PPP1CA Homo sapiens P62136
Far-WB
19389623
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Alzheimer'S Disease 1

  • Alzheimer Disease Type 1

  • Alzheimer'S Disease 1, Early Onset
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15107 TRPC4AP Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus TRPC4AP VGNC VGNC:66584
Mus musculus TRPC4AP MGD MGI:1930751
Canis familiaris TRPC4AP VGNC VGNC:47869
Bos taurus TRPC4AP VGNC VGNC:36384
Macaca mulatta TRPC4AP VGNC VGNC:79014
Rattus norvegicus TRPC4AP RGD RGD:1309914
Others TRPC4AP NCBI