2. Gene
  3. TRPC4AP - transient receptor potential cation channel subfamily C member 4 associated protein Gene

TRPC4AP - transient receptor potential cation channel subfamily C member 4 associated protein Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as TRUSS; TRRP4AP; PPP1R158; C20orf188

Gene ID: 26133 | Gene type: protein coding

About TRPC4AP

Cytogenetic location: 20q11.22 Genomic coordinates (GRCh38): 20:35,002,404-35,092,807 (from NCBI)

This gene has 2 transcripts (splice variants) and 232 orthologues. Ubiquitous expression in placenta (RPKM 20.6), spleen (RPKM 19.3) and 25 other tissues.

Summary

Enables Phosphatase binding activity and ubiquitin ligase-substrate adaptor activity. Involved in protein ubiquitination and ubiquitin-dependent protein catabolic process via the C-end degron rule pathway. Part of Cul4A-RING E3 ubiquitin ligase complex. Is active in Cul4-RING E3 ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]

TRPC4AP Products(2)

mRNA Protein Name
NM_015638.3 NP_056453.1 short transient receptor potential channel 4-associated protein isoform a
NM_199368.2 NP_955400.1 short transient receptor potential channel 4-associated protein isoform b

TRPC4AP Protein Structure

DUF3689

DUF3689: Protein of unknown function (DUF3689) (407 - 717)

  • 0
  • 200
  • 400
  • 600
  • 797 a.a.
Protein Preferred Names Protein Names

short transient receptor potential channel 4-associated protein

TNF-receptor ubiquitous scaffolding/signaling protein

Related Diseases

Diseases Alias
Alzheimer'S Disease 1

Alzheimer Disease Type 1

Alzheimer'S Disease 1, Early Onset
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15107 TRPC4AP Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus TRPC4AP VGNC VGNC:66584
Mus musculus TRPC4AP MGD MGI:1930751
Canis familiaris TRPC4AP VGNC VGNC:47869
Bos taurus TRPC4AP VGNC VGNC:36384
Macaca mulatta TRPC4AP VGNC VGNC:79014
Rattus norvegicus TRPC4AP RGD RGD:1309914