TIAM2 - TIAM Rac1 associated GEF 2 Gene

Homo sapiens

Also known as STEF; TIAM-2

Gene ID: 26230 | Gene type: protein coding

About TIAM2

Cytogenetic location: 6q25.2-q25.3 Genomic coordinates (GRCh38): 6:154,995,315-155,257,723 (from NCBI)

This gene has 20 transcripts (splice variants), 273 orthologues and 22 paralogues. Broad expression in testis (RPKM 5.7), brain (RPKM 4.1) and 18 other tissues.

Summary

This gene encodes a guanine nucleotide exchange factor. A highly similar mouse protein specifically activates ras-related C3 botulinum substrate 1, converting this Rho-like guanosine triphosphatase (GTPase) from a guanosine diphosphate-bound inactive state to a guanosine triphosphate-bound active state. The encoded protein may play a role in neural cell development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

TIAM2 Products(4)

mRNA	Protein	Name
NM_001010927.3	NP_001010927.2	rho guanine nucleotide exchange factor TIAM2 isoform b
NM_001384546.1	NP_001371475.1	rho guanine nucleotide exchange factor TIAM2 isoform a
NM_001384547.1	NP_001371476.1	rho guanine nucleotide exchange factor TIAM2 isoform a
NM_012454.4	NP_036586.3	rho guanine nucleotide exchange factor TIAM2 isoform a

TIAM2 Protein Structure

PDZ

RhoGEF

0
300
600
900
1200
1500
1701 a.a.

Protein Preferred Names

Protein Names

rho guanine nucleotide exchange factor TIAM2

SIF and TIAM1-like exchange factor

Related Diseases

Diseases

Alias

Lymphoma

Lymphoid Cancer	Lymphomas
Lymphoid Cancers	Lymphoid Neoplasm
Lymphoma Nos	Nhl - [Non-Hodgkin Lymphoma]
Non-Hodgkin Lymphoma	Non-Hodgkin Lymphoma, Nos
Non-Hodgkin Malignant Lymphoma Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14516	TIAM2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TIAM2	RGD	RGD:2324148
Bos taurus	TIAM2	VGNC	VGNC:96546
Felis catus	TIAM2	VGNC	VGNC:96551
Canis familiaris	TIAM2	VGNC	VGNC:81888
Macaca mulatta	TIAM2	VGNC	VGNC:81887
Mus musculus	TIAM2	MGD	MGI:1344338

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