FBXO9 - F-box protein 9 Gene

Also Known as FBX9; VCIA1; NY-REN-57; dJ341E18.2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 26268

About FBXO9

Cytogenetic location: 6p12.1 Genomic coordinates (GRCh38): 6:53,057,802-53,100,873 (from NCBI)

This gene has 13 transcripts (splice variants) and 208 orthologues. Ubiquitous expression in adrenal (RPKM 15.5), bone marrow (RPKM 13.7) and 25 other tissues.

Summary

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein Ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates at least 3 transcript variants diverging at the 5' terminus. [provided by RefSeq, Jul 2008]

FBXO9 Products (3)

mRNA	Protein	Name
NM_012347.4	NP_036479.1	F-box only protein 9 isoform 1
NM_033480.3	NP_258441.1	F-box only protein 9 isoform 2
NM_033481.3	NP_258442.2	F-box only protein 9 isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	22632967	GOA
enables ubiquitin-like ligase-substrate adaptor activity	IDA IDA: Inferred from direct assay	34480022	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	23263282	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	34480022	GOA
involved in protein K48-linked ubiquitination	IDA IDA: Inferred from direct assay	34480022	GOA
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	23263282	GOA
involved in regulation of TOR signaling	IMP IMP: Inferred from mutant phenotype	23263282	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of SCF ubiquitin ligase complex	IDA IDA: Inferred from direct assay	23263282	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	23263282	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FBXO9 Protein Structure

F-box-like

0
100
200
300
400
447 a.a.

Protein Preferred Names	Protein Names
F-box only protein 9	F-box protein Fbx9

FBXO9 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	FBXO9	Q9UK97	TELO2	Homo sapiens	Q9Y4R8	Anti Tag CoIP	23263282
Intra	FBXO9	Q9UK97	TELO2	Homo sapiens	Q9Y4R8	TAP	23263282
Intra	FBXO9	Q9UK97	TELO2	Homo sapiens	Q9Y4R8	Pull Down	23263282
Intra	FBXO9	Q9UK97	TTI1	Homo sapiens	O43156	Pull Down	23263282
Intra	FBXO9	Q9UK97	TTI1	Homo sapiens	O43156	Anti Tag CoIP	23263282
Intra	FBXO9	Q9UK97	TTI1	Homo sapiens	O43156	TAP	23263282
Intra	FBXO9	Q9UK97	SKP1	Homo sapiens	P63208	Anti Tag CoIP	22632967
Intra	FBXO9	Q9UK97	EEF2	Homo sapiens	P13639	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04815	FBXO9 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	FBXO9	VGNC	VGNC:62199
Rattus norvegicus	FBXO9	RGD	RGD:1310374
Bos taurus	FBXO9	VGNC	VGNC:28921
Macaca mulatta	FBXO9	VGNC	VGNC:72492
Mus musculus	FBXO9	MGD	MGI:1918788
Canis familiaris	FBXO9	VGNC	VGNC:40791
Others	FBXO9	NCBI