MYCBP - MYC binding protein Gene

Homo sapiens

Also known as AMY-1

Gene ID: 26292 | Gene type: protein coding

About MYCBP

Cytogenetic location: 1p34.3 Genomic coordinates (GRCh38): 1:38,862,490-38,873,378 (from NCBI)

This gene has 4 transcripts (splice variants) and 228 orthologues. Ubiquitous expression in testis (RPKM 11.1), colon (RPKM 10.6) and 25 other tissues.

Summary

The protein encoded by this gene binds to the N-terminus of the oncogenic protein c-Myc, enhancing the ability of c-Myc to activate E box-dependent transcription. The encoded protein is normally found in the cytoplasm, but it translocates to the nucleus during S phase of the cell cycle and associates with c-Myc. This protein may be involved in spermatogenesis. This gene can be silenced by microRNA-22. Two transcript variants, one protein-coding and the other probably not protein-coding, have been found for this gene. [provided by RefSeq, Nov 2011]

MYCBP Products(1)

mRNA	Protein	Name
NM_012333.5	NP_036465.2	C-Myc-binding protein

Protein Preferred Names

Protein Names

C-Myc-binding protein

associate of myc-1

Related Diseases

Diseases

Alias

Adult Liposarcoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08880	MYCBP Human Pre-designed siRNA Set A		/	Unkown
HY-RS08881	MYCBP2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	MYCBP	VGNC	VGNC:110177
Mus musculus	MYCBP	MGD	MGI:1891750
Rattus norvegicus	MYCBP	RGD	RGD:2320727

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