Map2k7 - mitogen-activated protein kinase kinase 7 Gene

Also Known as Mek7; Mkk7; sek2; Jnkk2; MEK 7; JNKK 2; Mapkk7; Prkmk7; MAPKK 7; 5930412N11Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 26400

Summary

Enables magnesium ion binding activity; protein kinase activity; and protein Phosphatase binding activity. Involved in several processes, including JNK cascade; cellular response to interleukin-1; and positive regulation of MAPK cascade. Acts upstream of or within regulation of motor neuron apoptotic process and response to wounding. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; lung; musculoskeletal system; and sensory organ. Used to study schizophrenia. Orthologous to human MAP2K7 (mitogen-activated protein kinase kinase 7). [provided by Alliance of Genome Resources, Apr 2022]

Map2k7 Products (6)

mRNA Protein Name
NM_001042557.2 NP_001036022.1 dual specificity mitogen-activated protein kinase kinase 7 isoform 1
NM_001164172.1 NP_001157644.1 dual specificity mitogen-activated protein kinase kinase 7 isoform 3
NM_001291777.1 NP_001278706.1 dual specificity mitogen-activated protein kinase kinase 7 isoform 4
NM_001291778.1 NP_001278707.1 dual specificity mitogen-activated protein kinase kinase 7 isoform 5
NM_001291783.1 NP_001278712.1 dual specificity mitogen-activated protein kinase kinase 7 isoform 6
NM_011944.3 NP_036074.2 dual specificity mitogen-activated protein kinase kinase 7 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables JUN kinase kinase activity IDA
IDA: Inferred from direct assay
9405446 MGI
enables MAP kinase activity IDA
IDA: Inferred from direct assay
9405446 MGI
enables magnesium ion binding IDA
IDA: Inferred from direct assay
9405446 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11959861 MGI
enables protein phosphatase binding IPI
IPI: Inferred from physical interaction
11959862 MGI
Biological Process GO Annotation Evidence References Source
involved in JNK cascade IDA
IDA: Inferred from direct assay
11959862 MGI
involved in cellular response to interleukin-1 IMP
IMP: Inferred from mutant phenotype
9405446 MGI
involved in cellular response to lipopolysaccharide IMP
IMP: Inferred from mutant phenotype
9405446 MGI
involved in positive regulation of JNK cascade IDA
IDA: Inferred from direct assay
9405446 MGI
involved in positive regulation of JUN kinase activity IDA
IDA: Inferred from direct assay
11959862 MGI
acts upstream of or within regulation of motor neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
25100604 MGI
acts upstream of or within response to wounding IMP
IMP: Inferred from mutant phenotype
25100604 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
9891090 MGI
located in nucleus IDA
IDA: Inferred from direct assay
9891090 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

dual specificity mitogen-activated protein kinase kinase 7

  • JNK kinase 2

  • JNK-activating kinase 2

  • MAP kinase kinase 7

  • MAPK/ERK kinase 7

  • c-Jun N-terminal kinase kinase 2

  • protein kinase, mitogen activated, kinase 7

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-171178 DK2403 98.24% Unkown
HY-D2415 BODIPY-FL staurosporine 95.4% Unkown
HY-RS08045 MAP2K7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19790 Map2k7 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26286 Map2k7 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Map2k7 NCBI NCBI:5609