2. Gene
  3. Mapk14 - mitogen-activated protein kinase 14 Gene

Mapk14 - mitogen-activated protein kinase 14 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as p38; Crk1; Mxi2; p38a; CSBP2; Csbp1; PRKM14; PRKM15; p38MAPK; p38alpha; p38-alpha

Gene ID: 26416 | Gene type: protein coding

About Mapk14

Chromosome 17: 28,910,303-28,967,380 forward strand.GRCm39:CM001010.3

This gene has 10 transcripts (splice variants), 295 orthologues, 19 paralogues and is associated with 49 phenotypes. Ubiquitous expression in spleen adult (RPKM 35.2), thymus adult (RPKM 34.4) and 28 other tissues.

Summary

Enables MAP kinase activity and NFAT protein binding activity. Involved in several processes, including p38MAPK cascade; positive regulation of cell differentiation; and skeletal system development. Acts upstream of or within several processes, including animal organ development; cell surface receptor signaling pathway; and positive regulation of cell differentiation. Located in several cellular components, including cytosol; mitochondrion; and spindle pole. Is active in glutamatergic synapse. Is expressed in several structures, including brain; early conceptus; epidermis; genitourinary system; and lung. Orthologous to human MAPK14 (mitogen-activated protein kinase 14). [provided by Alliance of Genome Resources, Apr 2022]

Mapk14 Products(5)

mRNA Protein Name
NM_011951.3 NP_036081.1 mitogen-activated protein kinase 14 isoform 1
NM_001168508.1 NP_001161980.1 mitogen-activated protein kinase 14 isoform 2
NM_001168513.1 NP_001161985.1 mitogen-activated protein kinase 14 isoform 3
NM_001168514.1 NP_001161986.1 mitogen-activated protein kinase 14 isoform 3
NM_001357724.1 NP_001344653.1 mitogen-activated protein kinase 14 isoform 3

Mapk14 Protein Structure

STKc_p38alpha

STKc_p38alpha: cd07877 (5 - 349)

  • 0
  • 100
  • 200
  • 300
  • 360 a.a.
Protein Preferred Names Protein Names

mitogen-activated protein kinase 14

MAP kinase 14

MAP kinase p38 alpha

MAPK 14

mitogen-activated protein kinase p38 alpha

p38 MAP kinase alpha

p38 MAPK

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-10401 VX-702 Inhibitor 99.54% Phase 2
Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-18874 p38-α MAPK-IN-1 Inhibitor 99.89% Unkown
HY-148061 DB1113 99.28% Unkown
HY-RS08107 MAPK14 Human Pre-designed siRNA Set A / Unkown
HY-RS08108 Mapk14 Mouse Pre-designed siRNA Set A / Unkown
HY-RS08109 Mapk14 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mapk14 NCBI NCBI:1432