Ecsit - ECSIT signalling integrator Gene

Also Known as Sitpec

Species: Mus musculus

Gene Type: protein coding
Gene ID: 26940

Summary

Enables DNA-binding transcription factor activity and chromatin binding activity. Acts upstream of or within BMP signaling pathway; mesoderm formation; and regulation of transcription by RNA polymerase II. Located in mitochondrion. Part of transcription regulator complex. Is expressed in several structures, including egg cylinder; embryo mesoderm; and genitourinary system. Orthologous to human ECSIT (ECSIT signaling integrator). [provided by Alliance of Genome Resources, Apr 2022]

Ecsit Products (3)

mRNA Protein Name
NM_001253897.1 NP_001240826.1 evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial precursor
NM_001253898.1 NP_001240827.1 evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial precursor
NM_012029.2 NP_036159.1 evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
14633973 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
14633973 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10465784 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within BMP signaling pathway IDA
IDA: Inferred from direct assay
14633973 MGI
acts upstream of or within cell surface receptor protein serine/threonine kinase signaling pathway IDA
IDA: Inferred from direct assay
10465784 MGI
acts upstream of or within cell surface receptor protein serine/threonine kinase signaling pathway IPI
IPI: Inferred from physical interaction
10465784 MGI
acts upstream of or within mesoderm formation IMP
IMP: Inferred from mutant phenotype
14633973 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
14633973 MGI
Cellular Component GO Annotation Evidence References Source
located in mitochondrion IDA
IDA: Inferred from direct assay
22588174 MGI
part of transcription regulator complex IDA
IDA: Inferred from direct assay
14633973 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

  • ECSIT homolog

  • signaling intermediate in Toll pathway-evolutionarily conserved

Ecsit Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Ecsit Q9QZH6 TRAF6 Homo sapiens Q9Y4K3
CoIP
10465784
Intra
Ecsit Q9QZH6 Rps27a Mus musculus P62991
Anti Tag CoIP
21525932
Intra
Ecsit Q9QZH6 Rps27a Mus musculus P62991
Anti Bait CoIP
21525932
Intra
Ecsit Q9QZH6 Traf6 Mus musculus P70196
Pull Down
10465784
Intra
Ecsit Q9QZH6 Traf6 Mus musculus P70196
Anti Bait CoIP
21525932
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04148 ECSIT Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20915 Ecsit Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27432 Ecsit Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ecsit NCBI NCBI:51295