ZBTB32 - zinc finger and BTB domain containing 32 Gene

Also Known as Rog; FAXF; FAZF; TZFP; ZNF538

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 27033

About ZBTB32

Cytogenetic location: 19q13.12 Genomic coordinates (GRCh38): 19:35,704,558-35,717,038 (from NCBI)

This gene has 6 transcripts (splice variants), 98 orthologues and 36 paralogues. Biased expression in testis (RPKM 13.5), lymph node (RPKM 1.5) and 2 other tissues.

Summary

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; identical protein binding activity; and sequence-specific double-stranded DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

ZBTB32 Products (3)

mRNA	Protein	Name
NM_001316902.2	NP_001303831.1	zinc finger and BTB domain-containing protein 32 isoform 2
NM_001316903.2	NP_001303832.1	zinc finger and BTB domain-containing protein 32 isoform 3
NM_014383.3	NP_055198.1	zinc finger and BTB domain-containing protein 32 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	10572087	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10572087	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	10572087	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZBTB32 Protein Structure

BTB

zf-H2C2_2

zf-met

0
100
200
300
400
487 a.a.

Protein Preferred Names	Protein Names
zinc finger and BTB domain-containing protein 32	FANCC-interacting protein

ZBTB32 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ZBTB32	Q9Y2Y4	RHOXF2	Homo sapiens	Q9BQY4	Y2H Array	20211142
Cross	ZBTB32	Q9Y2Y4	Hoxa1	Mus musculus	P09022	Pull Down	23088713

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Fanconi Anemia, Complementation Group A	Fanconi Anemia Fanconi Pancytopenia Fanconi Anemia Complementation Group A FANCA Fa Fanconi Panmyelopathy Fanconi'S Anemia Fanconi Anaemia Fanconi'S Anaemia Fanconi Hypoplastic Anemia Estren-Dameshek Variant Of Fanconi Anemia Estren-Dameshek Variant Of Fanconi Pancytopenia Fanconi Anemia Estren-Dameshek Variant Fanconis Anemia
Epithelial-Stromal Tgfbi Dystrophy
Lattice Corneal Dystrophy	Familial Amyloid Neuropathy, Finnish Type Familial Amyloid Polyneuropathy, Type V

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15971	ZBTB32 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ZBTB32	MGD	MGI:1891838
Bos taurus	ZBTB32	VGNC	VGNC:37072
Rattus norvegicus	ZBTB32	RGD	RGD:1584121
Others	ZBTB32	NCBI