BRPF3 - bromodomain and PHD finger containing 3 Gene

Homo sapiens

Gene ID: 27154 | Gene type: protein coding

About BRPF3

Cytogenetic location: 6p21.31 Genomic coordinates (GRCh38): 6:36,196,744-36,232,790 (from NCBI)

This gene has 12 transcripts (splice variants), 287 orthologues and 8 paralogues. Ubiquitous expression in testis (RPKM 15.9), kidney (RPKM 10.5) and 25 other tissues.

Summary

Predicted to enable histone binding activity. Involved in histone H3-K14 acetylation and positive regulation of DNA replication. Part of MOZ/MORF Histone Acetyltransferase complex. [provided by Alliance of Genome Resources, Apr 2022]

BRPF3 Products(7)

mRNA	Protein	Name
XM_047418649.1	XP_047274605.1	bromodomain and PHD finger-containing protein 3 isoform X1
XM_047418651.1	XP_047274607.1	bromodomain and PHD finger-containing protein 3 isoform X6
XM_011514492.2	XP_011512794.1	bromodomain and PHD finger-containing protein 3 isoform X5
XM_011514491.2	XP_011512793.1	bromodomain and PHD finger-containing protein 3 isoform X3
XM_011514490.2	XP_011512792.1	bromodomain and PHD finger-containing protein 3 isoform X2
XM_047418650.1	XP_047274606.1	bromodomain and PHD finger-containing protein 3 isoform X4
NM_015695.3	NP_056510.2	bromodomain and PHD finger-containing protein 3

BRPF3 Protein Structure

EPL1

PHD_2

zf-HC5HC2H_2

Bromodomain

PWWP

0
200
400
600
800
1000
1205 a.a.

Protein Preferred Names

Protein Names

bromodomain and PHD finger-containing protein 3

Related Diseases

Diseases

Alias

Lethal Congenital Contracture Syndrome 2

LCCS2	Lethal Congenital Contractural Syndrome 2
Multiple Contracture Syndrome, Israeli-Bedouin Type	Multiple Contracture Syndrome, Israeli Bedouin Type A
Multiple Contracture Syndrome, Israeli Bedouin Type	Lethal Congenital Contracture Syndrome Type 2
Israeli Bedouin Multiple Contracture Syndrome Type A	Contracture Syndrome, Lethal, Congenital, Type 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-107424	BAY-299	Inhibitor	99.24%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	BRPF3	VGNC	VGNC:26573
Felis catus	BRPF3	VGNC	VGNC:60182
Rattus norvegicus	BRPF3	RGD	RGD:1306868
Macaca mulatta	BRPF3	VGNC	VGNC:70309
Mus musculus	BRPF3	MGD	MGI:2146836
Canis familiaris	BRPF3	VGNC	VGNC:38534
Others	BRPF3	NCBI