BRPF3 - bromodomain and PHD finger containing 3 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 27154

About BRPF3

Cytogenetic location: 6p21.31 Genomic coordinates (GRCh38): 6:36,196,744-36,232,790 (from NCBI)

This gene has 12 transcripts (splice variants), 287 orthologues and 8 paralogues. Ubiquitous expression in testis (RPKM 15.9), kidney (RPKM 10.5) and 25 other tissues.

Summary

Predicted to enable histone binding activity. Involved in histone H3-K14 acetylation and positive regulation of DNA replication. Part of MOZ/MORF Histone Acetyltransferase complex. [provided by Alliance of Genome Resources, Apr 2022]

BRPF3 Products (7)

mRNA	Protein	Name
XM_047418649.1	XP_047274605.1	bromodomain and PHD finger-containing protein 3 isoform X1
XM_047418651.1	XP_047274607.1	bromodomain and PHD finger-containing protein 3 isoform X6
XM_011514492.2	XP_011512794.1	bromodomain and PHD finger-containing protein 3 isoform X5
XM_011514491.2	XP_011512793.1	bromodomain and PHD finger-containing protein 3 isoform X3
XM_011514490.2	XP_011512792.1	bromodomain and PHD finger-containing protein 3 isoform X2
XM_047418650.1	XP_047274606.1	bromodomain and PHD finger-containing protein 3 isoform X4
NM_015695.3	NP_056510.2	bromodomain and PHD finger-containing protein 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
contributes to histone H3K14 acetyltransferase activity	IDA IDA: Inferred from direct assay	16387653	GOA
contributes to histone H4K12 acetyltransferase activity	IDA IDA: Inferred from direct assay	16387653	GOA
contributes to histone H4K5 acetyltransferase activity	IDA IDA: Inferred from direct assay	16387653	GOA
contributes to histone H4K8 acetyltransferase activity	IDA IDA: Inferred from direct assay	16387653	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17474147	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of DNA replication	IDA IDA: Inferred from direct assay	26620551	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of MOZ/MORF histone acetyltransferase complex	IDA IDA: Inferred from direct assay	16387653	GOA
part of histone acetyltransferase complex	IDA IDA: Inferred from direct assay	26620551	GOA
located in nucleus	IDA IDA: Inferred from direct assay	25593309	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BRPF3 Protein Structure

EPL1

PHD_2

zf-HC5HC2H_2

Bromodomain

PWWP

0
200
400
600
800
1000
1205 a.a.

Protein Preferred Names	Protein Names
bromodomain and PHD finger-containing protein 3

BRPF3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	BRPF3	Q9ULD4	NCK1	Homo sapiens	P16333	Peptide Array	17474147

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Lethal Congenital Contracture Syndrome 2	LCCS2 Lethal Congenital Contractural Syndrome 2 Multiple Contracture Syndrome, Israeli-Bedouin Type Multiple Contracture Syndrome, Israeli Bedouin Type A Multiple Contracture Syndrome, Israeli Bedouin Type Lethal Congenital Contracture Syndrome Type 2 Israeli Bedouin Multiple Contracture Syndrome Type A Contracture Syndrome, Lethal, Congenital, Type 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-107424	BAY-299	Inhibitor	99.40%	Unkown
HY-101121	NI-42	Inhibitor	99.53%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	BRPF3	VGNC	VGNC:26573
Felis catus	BRPF3	VGNC	VGNC:60182
Rattus norvegicus	BRPF3	RGD	RGD:1306868
Macaca mulatta	BRPF3	VGNC	VGNC:70309
Mus musculus	BRPF3	MGD	MGI:2146836
Canis familiaris	BRPF3	VGNC	VGNC:38534
Others	BRPF3	NCBI