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IFNL2 - interferon lambda 2 Gene

Also Known as IL28A; IFNL2a; IFNL3a; IL-28A

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 282616

About IFNL2

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:39,268,396-39,270,188 (from NCBI)

This gene has 1 transcript (splice variant), 136 orthologues and 2 paralogues. Low expression observed in reference dataset.

Summary

This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28B (IL28B), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral Infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). [provided by RefSeq, Jul 2008]

IFNL2 Products (1)

mRNA	Protein	Name
NM_172138.2	NP_742150.1	interferon lambda-2 precursor

IFNL2 Protein Structure

IL28A

0
100
200 a.a.

Protein Preferred Names	Protein Names
interferon lambda-2	IFN-lambda-2

Recombinant IFNL2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72553	IFN-lambda 2/IL-28A Protein, Human (HEK293, His)	Q8IZJ0 (V26-V200)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P77005	IFN-lambda 2/IL-28A Protein, Human (P.pastoris, His)	Q8IZJ0 (V26-V200)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P700119AF	Animal-Free IFN-lambda 2/IL-28A Protein, Human (His)	Q8IZJ0 (P27-V200)	≥ 95%, as determined by reducing SDS-PAGE.

IFNL2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P84666	IL28A Antibody (YA4363)	WB, IHC-P, ELISA	Human
HY-P84666A	IL28A Antibody (YA4363)(PBS only)	WB, IHC-P, ELISA	Human

Related Diseases

Diseases	Alias
Psoriasis 12	PSORS12 Psoriasis Susceptibility 12 Psoriasis 12, Susceptibility To
Immunodeficiency 28	IMD28 Ifngr2 Deficiency Immunodeficiency 28, Mycobacteriosis, Autosomal Recessive Immunodeficiency 28, Mycobacteriosis Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Ifngammar2 Deficiency Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Interferon Gamma Receptor 2 Deficiency Msmd Due To Complete Ifngammar2 Deficiency Msmd Due To Complete Interferon Gamma Receptor 2 Deficiency Autosomal Recessive Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Ifngammar2 Deficiency Autosomal Recessive Msmd Due To Partial Ifngammar2 Deficiency Autosomal Recessive Msmd Due To Partial Interferon Gamma Receptor 2 Deficiency Autosomal Recessive Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Interferon Gamma Receptor 2 Deficiency Immunodeficiency, Type 28, Mycobacteriosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06592	IFNL2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174659	Human IFNL2 mRNA		/	Unkown