IFNL3 - interferon lambda 3 Gene

Homo sapiens

Also known as IL28B; IL28C; IL-28B; IL-28C; IFN-lambda-3; IFN-lambda-4

Gene ID: 282617 | Gene type: protein coding

About IFNL3

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:39,243,455-39,245,250 (from NCBI)

This gene has 2 transcripts (splice variants), 136 orthologues, 2 paralogues and is associated with 1 phenotype. Low expression observed in reference dataset.

Summary

This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral Infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). [provided by RefSeq, Jul 2008]

IFNL3 Products(2)

mRNA	Protein	Name
NM_001346937.2	NP_001333866.1	interferon lambda-3 isoform 1
NM_172139.4	NP_742151.2	interferon lambda-3 isoform 2 precursor

IFNL3 Protein Structure

IL28A

0
100
196 a.a.

Protein Preferred Names

Protein Names

interferon lambda-3

cytokine Zcyto22

Recombinant IFNL3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71969	IFN-lambda 3/IL-28B Protein, Human (HEK 293, His)	Q8IZI9 (V22-V196)	≥95%
HY-P73201	IFN-lambda 3/IL-28B Protein, Human (P.pastoris, His)	Q8IZI9 (V18-V196)	≥95%
HY-P72552	IFN-lambda 3/IL-28B Protein, Human (HEK293, His)	Q8IZI9 (V22-V196)	≥95%
HY-P700120AF	Animal-Free IFN-lambda 3/IL-28B Protein, Human (His)	Q8IZI9 (V22-V196)	≥95%

Related Diseases

Diseases

Alias

Hepatitis C Virus

Hepatitis C Virus, Susceptibility To	Hepatitis C Virus Infection, Response To Therapy Of
Hcv	Hcv, Susceptibility To
Hepatitis C Virus, Resistance To	Hepatitis C Virus, Response To Therapy Of
Resistance To Hepatitis C Virus

Cryoglobulinemia

Cryoimmunoglobulinaemia

Hepatitis D

Delta Hepatitis	Hepatitis Delta
Hdv	Hepatitis D Virus
Hepatitis D Infection

Viral Hepatitis

Animal Viral Hepatitis	Hepatitis, Viral, Animal
Human Viral Hepatitis	Viral Hepatitis With Hepatic Coma

Hepatitis E

Liver Cirrhosis

Cirrhosis	Cirrhosis Of Liver
CIRRH	Cryptogenic Cirrhosis
Cirrhosis, Cryptogenic	Cirrhosis Nos

Abacavir Allergy

Abc Allergy

Esophageal Varix

Esophageal Varices	Bleeding Esophageal Varices
Bleeding Oesophageal Varices	Esophageal Varices In Disease Classified Elsewhere, With Bleeding
Esophageal Varices With Bleeding	Esophageal Varices With Bleeding In Disease Ec
Esophageal Varices Without Bleeding	Esophageal Varices Without Mention Of Bleeding

Bilirubin Metabolic Disorder

Hyperbilirubinemia	Hereditary Hyperbilirubinemia
Hyperbilirubinemia, Hereditary	Hyperbilirubinaemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06593	IFNL3 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	IFNL3	RGD	RGD:1589046
Mus musculus	IFNL3	NCBI

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