Ppif - peptidylprolyl isomerase F Gene

Also Known as CypD; CyP-D; PPIase

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 282819

Summary

Enables cyclosporin A binding activity and peptidyl-prolyl cis-trans isomerase activity. Involved in regulation of apoptotic process and regulation of mitochondrial membrane permeability. Located in mitochondrial inner membrane and mitochondrial matrix. Orthologous to human PPIF (peptidylprolyl isomerase F). [provided by Alliance of Genome Resources, Apr 2022]

Ppif Products (1)

mRNA Protein Name
NM_172243.2 NP_758443.1 peptidyl-prolyl cis-trans isomerase F, mitochondrial precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cyclosporin A binding IDA
IDA: Inferred from direct assay
1599421 RGD
enables peptide binding IDA
IDA: Inferred from direct assay
15233627 RGD
enables peptidyl-prolyl cis-trans isomerase activity IDA
IDA: Inferred from direct assay
1599421 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
9820802 RGD
Biological Process GO Annotation Evidence References Source
involved in regulation of apoptotic process IDA
IDA: Inferred from direct assay
15233627 RGD
involved in regulation of mitochondrial membrane permeability IDA
IDA: Inferred from direct assay
15233627 RGD
Cellular Component GO Annotation Evidence References Source
located in mitochondrial inner membrane IDA
IDA: Inferred from direct assay
9820802 RGD
is active in mitochondrial matrix IDA
IDA: Inferred from direct assay
20884751 RGD
located in mitochondrial matrix IDA
IDA: Inferred from direct assay
1599421 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

peptidyl-prolyl cis-trans isomerase F, mitochondrial

  • PPIase F

  • cyclophilin D

  • cyclophilin F

  • rotamase F

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10951 PPIF Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-179416 CypD-IN-6 Inhibitor / Unkown
HY-179417 CypD-IN-7 Inhibitor / Unkown
HY-RS18784 Ppif Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25273 Ppif Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ppif NCBI NCBI:10105