GPR17 - G protein-coupled receptor 17 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2840

About GPR17

Cytogenetic location: 2q14.3 Genomic coordinates (GRCh38): 2:127,646,153-127,652,639 (from NCBI)

This gene has 6 transcripts (splice variants), 189 orthologues and 16 paralogues. Biased expression in brain (RPKM 16.2), endometrium (RPKM 2.8) and 5 other tissues.

Summary

Predicted to enable G protein-coupled receptor activity. Predicted to be involved in positive regulation of Rho protein signal transduction and positive regulation of cytosolic calcium ion concentration involved in Phospholipase C-activating G protein-coupled signaling pathway. Predicted to act upstream of or within negative regulation of inflammatory response to antigenic stimulus. Predicted to be located in plasma membrane. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

GPR17 Products (4)

mRNA Protein Name
NM_001161415.2 NP_001154887.1 uracil nucleotide/cysteinyl leukotriene receptor isoform a
NM_001161416.2 NP_001154888.1 uracil nucleotide/cysteinyl leukotriene receptor isoform b
NM_001161417.2 NP_001154889.1 uracil nucleotide/cysteinyl leukotriene receptor isoform b
NM_005291.3 NP_005282.1 uracil nucleotide/cysteinyl leukotriene receptor isoform a

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
36613703 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GPR17 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (76 - 325)

  • 0
  • 100
  • 200
  • 300
  • 367 a.a.
Protein Preferred Names Protein Names

uracil nucleotide/cysteinyl leukotriene receptor

  • P2Y-like receptor

Related Diseases

Diseases Alias
Strabismic Amblyopia

  • Suppression Amblyopia

  • Amblyopia

  • Amblyopia, Suppression
Persistent Mild Asthma
Periventricular Leukomalacia

  • Leukomalacia, Periventricular

  • Pvl

  • Leukomalacia Periventricular
Encephalomalacia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-19638A Cangrelor tetrasodium Antagonist 99.96% Unkown
HY-19638 Cangrelor Antagonist / Unkown

Pre-clinical Phase

Bioactive Molecules (16)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-146486 P2Y2R/GPR17 antagonist 1 Inhibitor 98.09% Unkown
HY-111323 ASN06917370 99.23% Unkown
HY-128111 ASN02563583 Activator 99.21% Unkown
HY-113667 ASN04885796 Activator 99.40% Unkown
HY-170589 GPR17 antagonist 1 Antagonist 98.95% Unkown
HY-128128 ASN04421891 Modulator 99.00% Unkown
HY-107752A 2-(Phenylethynyl)-ATP ammonium / Unkown
HY-125313 PSB-1737 Agonist / Unkown
HY-159920 PSB-22269 Antagonist / Unkown
HY-164311 GPR17 modulator-1 Modulator / Unkown
HY-179606 RWT9996 / Unkown
HY-181738 GPR17 agonist 2 / Unkown
HY-182724 PSB-18422 Agonist / Unkown
HY-RS05679 GPR17 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17462 Gpr17 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23920 Gpr17 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus GPR17 VGNC VGNC:29568
Macaca mulatta GPR17 VGNC VGNC:73126
Mus musculus GPR17 MGD MGI:3584514
Canis familiaris GPR17 VGNC VGNC:41414
Rattus norvegicus GPR17 RGD RGD:1589785
Felis catus GPR17 VGNC VGNC:67417
Others GPR17 NCBI