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284680

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-120623
    BMS-284640

    		Na+/H+ Exchanger (NHE) Neurological Disease
    BMS-284640 is a synthetic sodium hydrogen exchange isomer-1 (NHE-1) inhibitor. BMS-284640 has a more than 380-fold higher NHE-1 inhibitory activity (IC50: 9 nM) compared to cariporide (HY-19693) and is more selective for NHE-1 over NHE-2 (IC50: 1.8 μM) and NHE-5 (IC50: 3.36 μM). BMS-284640 and its analogs also exhibit enhanced oral bioavailability and prolonged plasma half-life in rats. .
    BMS-284640

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