Asic3 - acid sensing ion channel subunit 3 Gene

Also Known as Accn3

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 286920

Summary

Enables ligand-gated Sodium Channel activity. Involved in ion transmembrane transport. Acts upstream of or within response to acidic pH and sodium ion transport. Located in perinuclear region of cytoplasm and plasma membrane. Is integral component of plasma membrane. Orthologous to human ASIC3 (acid sensing ion channel subunit 3). [provided by Alliance of Genome Resources, Apr 2022]

Asic3 Products (1)

mRNA Protein Name
NM_173135.2 NP_775158.1 acid-sensing ion channel 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ligand-gated sodium channel activity IDA
IDA: Inferred from direct assay
9261094 RGD
enables ligand-gated sodium channel activity IMP
IMP: Inferred from mutant phenotype
9261094 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
11457882 RGD
Biological Process GO Annotation Evidence References Source
involved in monoatomic ion transmembrane transport IDA
IDA: Inferred from direct assay
16234233 RGD
acts upstream of or within response to acidic pH IDA
IDA: Inferred from direct assay
9261094 RGD
acts upstream of or within sodium ion transport IDA
IDA: Inferred from direct assay
9261094 RGD
involved in sodium ion transport IMP
IMP: Inferred from mutant phenotype
9261094 RGD
Cellular Component GO Annotation Evidence References Source
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
16234233 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
9261094 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

acid-sensing ion channel 3

  • DRASIC

  • acid-sensing (proton-gated) ion channel 3

  • amiloride-sensitive cation channel 3

  • dorsal root ASIC

  • proton gated cation channel DRASIC

Asic3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Asic3 O35240 Stoml3 Rattus norvegicus D4A100
Anti Tag CoIP
17167420
Cross
Asic3 O35240 Stom Mus musculus P54116
Anti Tag CoIP
22850675
Cross
Asic3 O35240 Stom Mus musculus P54116
BiFC
22850675
Cross
Asic3 O35240 Stom Mus musculus P54116
IF
22850675
Cross
Asic3 O35240 Patj Mus musculus Q63ZW7-3
Pull Down
11872753
Intra
Asic3 O35240 Nherf1 Rattus norvegicus Q9JJ19
IF
16234233
Intra
Asic3 O35240 Nherf1 Rattus norvegicus Q9JJ19
Y2H
16234233
Intra
Asic3 O35240 Nherf1 Rattus norvegicus Q9JJ19
Anti Tag CoIP
16234233
Intra
Asic3 O35240 Nherf2 Rattus norvegicus Q920G2
Y2H
16234233
Intra
Asic3 O35240 Nherf2 Rattus norvegicus Q920G2
Anti Tag CoIP
16234233
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (17)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-D0814 DAPI dihydrochloride Inhibitor 99.90% Unkown
HY-D1738 DAPI dilactate 99.0% Unkown
HY-D2868 DAPI Inhibitor 98.01% Unkown
HY-107757 GMQ hydrochloride Activator 99.86% Unkown
HY-122135 A-317567 Inhibitor 99.34% Unkown
HY-131879 NS383 99.83% Unkown
HY-DY1081 DAPI dihydrochloride (solution) Inhibitor / Unkown
HY-P1346A APETx2 TFA Inhibitor 99.57% Unkown
HY-P1441A Mambalgin 1 TFA Inhibitor 95.72% Unkown
HY-100939 4-Chlorophenylguanidine hydrochloride Agonist 99.07% Unkown
HY-P1346 APETx2 Inhibitor / Unkown
HY-155017 6-Iodoamiloride Inhibitor / Unkown
HY-P1249 Neuropeptide SF(mouse,rat) Agonist / Unkown
HY-P1249A Neuropeptide SF(mouse,rat) TFA Agonist / Unkown
HY-RS01091 ASIC3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17225 Asic3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23678 Asic3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Asic3 NCBI NCBI:9311