Parp2 - poly (ADP-ribose) polymerase 2 Gene

Also Known as Adprtl2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 290027

About Parp2

Primary_assembly 15: 24,034,106-24,044,338 forward strand.mRatBN7.2:CM026988.1

This gene has 2 transcripts (splice variants), 185 orthologues, 2 paralogues and is associated with 2 phenotypes.

Summary

Predicted to enable nucleosome binding activity and pentosyltransferase activity. Involved in negative regulation of neuron death and positive regulation of cell growth involved in cardiac muscle cell development. Predicted to be located in nucleoplasm and site of DNA damage. Predicted to be active in nucleolus. Orthologous to human PARP2 (poly(ADP-ribose) polymerase 2). [provided by Alliance of Genome Resources, Apr 2022]

Parp2 Products (1)

mRNA Protein Name
NM_001106030.1 NP_001099500.1 poly [ADP-ribose] polymerase 2

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in hippocampal neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
19422384 RGD
involved in positive regulation of cell growth involved in cardiac muscle cell development IMP
IMP: Inferred from mutant phenotype
23261455 RGD
involved in response to oxygen-glucose deprivation IMP
IMP: Inferred from mutant phenotype
19422384 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

poly [ADP-ribose] polymerase 2

  • ADP-ribosyltransferase (NAD+, poly(ADP-ribose) polymerase)-like 2

  • poly (ADP-ribose) polymerase family, member 2

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (13)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10162 Olaparib Inhibitor 99.98% Yes
HY-16106 Talazoparib Inhibitor 99.89% Unkown
HY-10619 Niraparib Inhibitor 99.96% Yes
HY-10617A Rucaparib Inhibitor 99.96% Yes
HY-10619A Niraparib hydrochloride Inhibitor 99.41% Yes
HY-10617 Rucaparib phosphate Inhibitor 99.76% Yes
HY-10619B Niraparib tosylate Inhibitor 99.99% Yes
HY-102003 Rucaparib monocamsylate Inhibitor 99.91% Yes
HY-10619E Niraparib tosylate hydrate Inhibitor 99.97% Yes
HY-102003A Rucaparib camsylate Inhibitor / Unkown
HY-10617C Rucaparib tartrate Inhibitor / Unkown
HY-10617D Rucaparib acetate Inhibitor / Unkown
HY-10617B Rucaparib hydrochloride Inhibitor / Unkown

Clinical Phase

Bioactive Molecules (11)
Cat. No. Product Name Effect
Purity Phase
HY-132167 Saruparib Inhibitor 99.76% Phase 3
HY-10129 Veliparib Inhibitor 99.77% Phase 3
HY-12418 Stenoparib Inhibitor 98.0% Phase 2
HY-137457 Venadaparib Inhibitor 98.52% Phase 2
HY-145584 Nesuparib Inhibitor 99.54% Phase 2
HY-122661 Mefuparib hydrochloride Inhibitor 98.62% Phase 2
HY-105303 CEP-9722 Inhibitor / Phase 2
HY-150207 RBN-3143 Inhibitor 99.29% Phase 1
HY-13536 AZD-2461 Inhibitor 99.79% Phase 1
HY-115552 Simmiparib Inhibitor 99.01% Phase 1
HY-170432 PARP1-IN-34 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (58)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15147 XAV-939 Inhibitor 99.91% Unkown
HY-13688A PJ34 Inhibitor 99.66% Unkown
HY-13990 NVP-TNKS656 Inhibitor 99.68% Unkown
HY-148566 OUL232 Inhibitor 99.86% Unkown
HY-14478 UPF 1069 Inhibitor 99.02% Unkown
HY-13688 PJ34 hydrochloride Inhibitor 99.81% Unkown
HY-100225 ME0328 Inhibitor 99.64% Unkown
HY-75706 N-Descyclopropanecarbaldehyde Olaparib Inhibitor 99.46% Unkown
HY-10130 Veliparib dihydrochloride Inhibitor 99.98% Yes
HY-12975 AZ6102 Inhibitor 99.53% Unkown
HY-19351 MN-64 Inhibitor 99.61% Unkown
HY-108632 BYK204165 Inhibitor 99.89% Unkown
HY-18954 NMS-P118 Inhibitor 99.54% Unkown
HY-156419 PARP7-IN-16 Inhibitor 99.91% Unkown
HY-156419A PARP7-IN-16 free base Inhibitor 99.40% Unkown
HY-148754 PARP10-IN-3 Inhibitor 98.72% Unkown
HY-132297A PARP1-IN-5 dihydrochloride Inhibitor 97.56% Unkown
HY-149800 PARP-1-IN-3 Inhibitor 99.80% Unkown
HY-10614 A-966492 Inhibitor 99.00% Unkown
HY-145749 PARPYnD Inhibitor 98.86% Unkown
HY-147886 PARP1-IN-11 Inhibitor 99.42% Unkown
HY-155993 YCH1899 Inhibitor 99.39% Unkown
HY-148753 PARP10-IN-2 Inhibitor 98.07% Unkown
HY-133124 PARP/PI3K-IN-1 Inhibitor 99.40% Unkown
HY-121719 TIQ-A Inhibitor 99.85% Unkown
HY-183013 PROTAC PARP2 degrader-1 Degrader 95.86% Unkown
HY-105692 DR2313 Inhibitor 99.66% Unkown
HY-185459 PCIP-1 Inhibitor 98.80% Unkown
HY-102035 PARP-2-IN-1 Inhibitor 99.56% Unkown
HY-146336 PARP1/2/TNKS1/2-IN-1 Inhibitor 98.66% Unkown
HY-143338 ART-IN-1 Inhibitor 98.91% Unkown
HY-176713 KWZY-11 Inhibitor / Unkown
HY-130646 iVeliparib-AP6 Degrader / Unkown
HY-137457A Venadaparib hydrochloride Inhibitor / Unkown
HY-132297 PARP1-IN-5 Inhibitor / Unkown
HY-145584A Nesuparib hydrochloride Inhibitor / Unkown
HY-W294889 OUL245 Inhibitor / Unkown
HY-105253 PARP-2/1-IN-2 Inhibitor / Unkown
HY-14687 (rac)-Talazoparib Inhibitor / Unkown
HY-158334 NDs-IN-1 Inhibitor / Unkown
HY-168851 PARP1-IN-35 Inhibitor / Unkown
HY-181928 PARP1/c-Met-IN-3 Inhibitor / Unkown
HY-180809 YCH3292 Inhibitor / Unkown
HY-179406 PARP1-IN-49 Inhibitor / Unkown
HY-151625 PARP-2-IN-3 Inhibitor / Unkown
HY-161606 PARP-1/2/7-IN-1 Inhibitor / Unkown
HY-179386 PARP1/EZH2-IN-1 Inhibitor / Unkown
HY-181265 PARP1-IN-53 Inhibitor / Unkown
HY-179020 PARP/VEGFR3-IN-1 Inhibitor / Unkown
HY-174828 ATR/PARP1-IN-1 Inhibitor / Unkown
HY-100847 AZ0108 Inhibitor / Unkown
HY-171543 PARP1-IN-37 Inhibitor / Unkown
HY-178032 PARP1-IN-44 Inhibitor / Unkown
HY-179349 PARP-1/2-IN-5 Inhibitor / Unkown
HY-169299 TOPOI/PARP-1-IN-2 Inhibitor / Unkown
HY-182246 MC2050 Inhibitor / Unkown
HY-172747 TNKS-2-IN-3 Inhibitor / Unkown
HY-14477 UPF-1035 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Parp2 NCBI NCBI:10038