Pak4 - p21 (RAC1) activated kinase 4 Gene

Rattus norvegicus

Gene ID: 292756 | Gene type: protein coding

About Pak4

Primary_assembly 1: 83,849,904-83,859,413 reverse strand.mRatBN7.2:CM026974.1

This gene has 1 transcript (splice variant), 162 orthologues, 36 paralogues and is associated with 6 phenotypes. Biased expression in Lung (RPKM 45.3), Adrenal (RPKM 43.4) and 9 other tissues.

Summary

Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in several processes, including negative regulation of endothelial cell apoptotic process; positive regulation of angiogenesis; and regulation of MAPK cascade. Predicted to act upstream of or within cellular response to organic cyclic compound and dendritic spine development. Predicted to be active in cytoplasm. Orthologous to human PAK4 (p21 (RAC1) activated kinase 4). [provided by Alliance of Genome Resources, Apr 2022]

Pak4 Products(1)

mRNA	Protein	Name
NM_001106238.1	NP_001099708.1	serine/threonine-protein kinase PAK 4

Pak4 Protein Structure

CRIB_PAK_like

PKc_like

0
100
200
300
400
500
593 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein kinase PAK 4

p21 (CDKN1A)-activated kinase 4	p21 protein (Cdc42/Rac)-activated kinase 4
p21-activated kinase 4

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-12793	Padnarsertib	Inhibitor	99.86%	Phase 2
HY-13007	PF-3758309	Inhibitor	99.84%	Phase 1

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-19538	FRAX1036	Inhibitor	98.88%	Unkown
HY-125035	LCH-7749944	Inhibitor	99.36%	Unkown
HY-13007B	PF-3758309 dihydrochloride	Inhibitor	/	Unkown
HY-13007A	PF-3758309 hydrochloride	Inhibitor	/	Unkown
HY-146681	PAK1-IN-1	Inhibitor	/	Unkown
HY-130628	PAK4-IN-1	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pak4	NCBI	NCBI:10298

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