CZh226 hydrochloride
CZh226 hydrochloride is a potent and selective PAK4 inhibitor with an IC50 of 18 nM, and its selectivity for PAK1 is 346 times. The oral bioavailability of CZh226 hydrochloride is poor, and it requires the use of the prodrug PAK4-IN-1 (HY-130628) to improve absorption and metabolic stability. CZh226 hydrochloride can be used for research on colorectal cancer and melanoma.
For research use only. We do not sell to patients.
- CAS No.: 2231440-94-9
- Formula: C20H23Cl2N7O
- Molecular Weight:448.35
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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PAK4 18 nM (IC50) |
Chemical Information
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CAS No. 2231440-94-9
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Molecular Weight 448.35
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Formula C20H23Cl2N7O
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SMILES
O=C(N1C[C@H](NCC1)C)C2=NC(C=CC(Cl)=C3)=C3C(NC4=NNC(C5CC5)=C4)=N2.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CZh226 hydrochloride Related Classifications
HY-111103A Related Classifications
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