CZh226 hydrochloride
CZh226 hydrochloride is a potent and selective PAK4 inhibitor with an IC50 of 18 nM, and its selectivity for PAK1 is 346 times. The oral bioavailability of CZh226 hydrochloride is poor, and it requires the use of the prodrug PAK4-IN-1 (HY-130628) to improve absorption and metabolic stability. CZh226 hydrochloride can be used for research on colorectal cancer and melanoma.
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- CAS No.: 2231440-94-9
- Formule: C20H23Cl2N7O
- Masse moléculaire:448.35
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
PAK4 18 nM (IC50) |
Chemical Information
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CAS No. 2231440-94-9
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Masse moléculaire 448.35
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Formule C20H23Cl2N7O
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SMILES
O=C(N1C[C@H](NCC1)C)C2=NC(C=CC(Cl)=C3)=C3C(NC4=NNC(C5CC5)=C4)=N2.Cl
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CZh226 hydrochloride Related Classifications
HY-111103A Related Classifications
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