CPS-021
CPS-021 is a selective PAK4 PROTAC degrader with a DC50 of 50 nM. CPS-021 has potent antimigratory and invasive activity and significantly suppresses the invasion and metastasis of tumor cells in A549-luc lung metastasis mice model. Pink: PAK4 ligand (HY-174822); Blue: CRBN ligase ligand (HY-10984); Black: linker
(Pink: PAK4 ligand (HY-174822); Blue: Cereblon ligand (HY-10984); Black: linker).
For research use only. We do not sell to patients.
- Formula: C52H63N11O7
- Molecular Weight:954.13
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All PROTACs Isoforms
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Biological Activity
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PAK4 50 nM (DC50) |
| Species | Dose | Route | T1/2 | C0 | Cmax | AUC0-∞ | AUC0-t | CL | Vss | Tmax | F |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Mice | 1 mg/kg | i.v. | 3.32 h | 657.7 ng/mL | 459.9 ng/mL | 332.62 ng·h/mL | 321.84 ng·h/mL | 52.12 mL/min/kg | 8.59 L/kg | / | / |
| Mice | 2 mg/kg | i.p. | 1.36 h | / | 343.11 ng/mL | 1220.51 ng·h/mL | 312.84 ng·h/mL | / | / | 2 h | 183.47 % |
Chemical Information
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Molecular Weight 954.13
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Formula C52H63N11O7
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SMILES
O=C(N1CCN(CC1)CCCCCCCC(N2CCN(CC2)CCNC3=CC=CC4=C3C(N(C4=O)C5CCC(NC5=O)=O)=O)=O)C(C6=CC=C(C#CC7(O)CCCCC7)C=C86)=CN8C9=NC(N)=NC=C9
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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