PAK4 - p21 (RAC1) activated kinase 4 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10298

About PAK4

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:39,125,786-39,182,816 (from NCBI)

This gene has 12 transcripts (splice variants), 162 orthologues and 35 paralogues. Ubiquitous expression in prostate (RPKM 14.9), kidney (RPKM 12.6) and 25 other tissues.

Summary

PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to Cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin Cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

PAK4 Products (18)

mRNA Protein Name
XM_011526320.2 XP_011524622.1 serine/threonine-protein kinase PAK 4 isoform X2
XM_047438036.1 XP_047293992.1 serine/threonine-protein kinase PAK 4 isoform X1
XM_011526317.3 XP_011524619.1 serine/threonine-protein kinase PAK 4 isoform X1
XM_011526316.2 XP_011524618.1 serine/threonine-protein kinase PAK 4 isoform X1
NM_001394501.1 NP_001381430.1 serine/threonine-protein kinase PAK 4 isoform 1
XM_047438041.1 XP_047293997.1 serine/threonine-protein kinase PAK 4 isoform X2
XM_047438035.1 XP_047293991.1 serine/threonine-protein kinase PAK 4 isoform X1
XM_047438034.1 XP_047293990.1 serine/threonine-protein kinase PAK 4 isoform X1
XM_024451314.2 XP_024307082.1 serine/threonine-protein kinase PAK 4 isoform X2
NM_001014833.1
XM_047438040.1 XP_047293996.1 serine/threonine-protein kinase PAK 4 isoform X2
XM_047438038.1 XP_047293994.1 serine/threonine-protein kinase PAK 4 isoform X1
NM_001014835.2 NP_001014835.1 serine/threonine-protein kinase PAK 4 isoform 2
NM_001014832.2 NP_001014832.1 serine/threonine-protein kinase PAK 4 isoform 1
NM_001014834.3 NP_001014834.1 serine/threonine-protein kinase PAK 4 isoform 2
NM_001014831.3 NP_001014831.1 serine/threonine-protein kinase PAK 4 isoform 1
XM_047438037.1 XP_047293993.1 serine/threonine-protein kinase PAK 4 isoform X1
NM_005884.5 NP_005875.1 serine/threonine-protein kinase PAK 4 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15161933 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
26607847 GOA
enables protein serine/threonine kinase activity IMP
IMP: Inferred from mutant phenotype
21788589 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of endothelial cell apoptotic process IMP
IMP: Inferred from mutant phenotype
21788589 GOA
involved in positive regulation of angiogenesis IMP
IMP: Inferred from mutant phenotype
21788589 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PAK4 Protein Structure

PBD

PBD: P21-Rho-binding domain (10 - 63)

Pkinase

Pkinase: Protein kinase domain (326 - 572)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 591 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase PAK 4

  • p21 protein (Cdc42/Rac)-activated kinase 4

  • p21(CDKN1A)-activated kinase 4

  • protein kinase related to S. cerevisiae STE20, effector for Cdc42Hs

PAK4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PAK4 O96013 INKA1 Homo sapiens Q96EL1
Validated Y2H
32296183
Intra
PAK4 O96013 INKA1 Homo sapiens Q96EL1
Y2H Array
32296183
Intra
PAK4 O96013 INKA1 Homo sapiens Q96EL1
Y2H Prey Pooling
32296183
Intra
PAK4 O96013 YWHAZ Homo sapiens P63104
Pull Down
15161933
Intra
PAK4 O96013 YWHAZ Homo sapiens P63104
Pull Down
32707033
Intra
PAK4 O96013 YWHAZ Homo sapiens P63104
Anti Tag CoIP
33961781
Intra
PAK4 O96013 YWHAZ Homo sapiens P63104
CoIP
15324660
Intra
PAK4 O96013 YWHAZ Homo sapiens P63104
Anti Tag CoIP
29100370
Intra
PAK4 O96013 YWHAE Homo sapiens P62258
Anti Tag CoIP
29100370
Intra
PAK4 O96013 YWHAE Homo sapiens P62258
Pull Down
32707033
Intra
PAK4 O96013 YWHAE Homo sapiens P62258
Anti Tag CoIP
35271311
Intra
PAK4 O96013 YWHAE Homo sapiens P62258
Crosslink
36931259
Intra
PAK4 O96013 SFN Homo sapiens P31947
TAP
15778465
Intra
PAK4 O96013 SFN Homo sapiens P31947
Crosslink
36931259
Intra
PAK4 O96013 TERF1 Homo sapiens P54274
Pull Down
21044950
Intra
PAK4 O96013 CDC42 Homo sapiens P60953
Pull Down
32707033
Intra
PAK4 O96013 CDC42 Homo sapiens P60953
Anti Bait CoIP
17353931
Intra
PAK4 O96013 WASL Homo sapiens O00401
Anti Bait CoIP
29100370
Intra
PAK4 O96013 WASL Homo sapiens O00401
Anti Tag CoIP
29100370
Intra
PAK4 O96013 WASL Homo sapiens O00401
Confocal
29100370
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PAK4 Proteins

Cat. No. Product Name Accession Purity
HY-P700575 PAK4 Protein, Human (His-SUMO) O96013-2 (M1-R426) ≥ 90%, as determined by reducing SDS-PAGE.

PAK4 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83588 Phospho-PAK4/5/6 (Ser474/Ser560/Ser602) Antibody (YA3333) WB Human, Mouse, Rat
HY-P83588A Phospho-PAK4/5/6 (Ser474/Ser560/Ser602) Antibody (YA3333)(PBS only) WB Human, Mouse, Rat
HY-P87028 Phospho-PAK4+PAK5+PAK6 (S474 + S560 + S602) Antibody (YA6721) WB Human

Related Diseases

Diseases Alias
Endometrial Cancer

  • Endometrial Carcinoma

  • Endometrial Neoplasm

  • Malignant Neoplasm Of Endometrium

  • Endometrioid Carcinoma

  • Endometrial Neoplasms

  • Carcinoma, Endometrioid

  • Endometrial Cancer, Familial

  • Endometrial Carcinoma, Somatic

  • Endometrial Cancer, Susceptibility To

  • Endometrial Ca

  • Malignant Endometrial Neoplasm

  • Neoplasm Of Endometrium

  • Primary Malignant Neoplasm Of Endometrium

  • Tumor Of Endometrium

  • Carcinoma Of The Endometrium

  • Endometrioid Carcinoma Of Female Reproductive System

  • ENDMC

  • Carcinoma Endometrioid

  • Endometrial Cancers

  • Cancer, Endometrial

  • Uterine Corpus Cancer
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-12793 Padnarsertib Inhibitor 99.58% Phase 2
HY-13007 PF-3758309 Inhibitor 99.79% Phase 1

Pre-clinical Phase

Bioactive Molecules (16)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-19538 FRAX1036 Inhibitor 98.88% Unkown
HY-125035 LCH-7749944 Inhibitor 99.68% Unkown
HY-143490 PAK4-IN-2 Inhibitor 99.42% Unkown
HY-N8389 Globulol Inhibitor 99.74% Unkown
HY-184396 GR2-128 Inhibitor / Unkown
HY-146681 PAK1-IN-1 Inhibitor / Unkown
HY-130628 PAK4-IN-1 Inhibitor / Unkown
HY-13007B PF-3758309 dihydrochloride Inhibitor / Unkown
HY-159897 PAK4-IN-5 Inhibitor / Unkown
HY-13007A PF-3758309 hydrochloride Inhibitor / Unkown
HY-183941 SPU-106 Inhibitor / Unkown
HY-111103A CZh226 hydrochloride Inhibitor / Unkown
HY-174247 CPS-021 Degrader / Unkown
HY-111103 CZh226 Inhibitor / Unkown
HY-117218 KY-04045 Inhibitor / Unkown
HY-181092 PAK4-IN-7 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris PAK4 VGNC VGNC:53528
Mus musculus PAK4 MGD MGI:1917834
Rattus norvegicus PAK4 RGD RGD:1307705
Others PAK4 NCBI