Mapt - microtubule-associated protein tau Gene

Also Known as Tau; pTau; Mtapt; RNPTAU; MAPT_0N4R

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29477

About Mapt

Primary_assembly 10: 89,138,627-89,236,129 forward strand.mRatBN7.2:CM026983.1

This gene has 9 transcripts (splice variants), 225 orthologues, 2 paralogues and is associated with 51 phenotypes. Biased expression in Brain (RPKM 355.), Kidney (RPKM 158.3) and 4 other tissues.

Summary

Enables several functions, including HSP90 protein binding activity; chaperone binding activity; and enzyme binding activity. Involved in several processes, including intrinsic apoptotic signaling pathway in response to oxidative stress; mRNA transport; and positive regulation of long-term synaptic depression. Located in several cellular components, including axon; cytoplasmic side of plasma membrane; and neuronal cell body. Colocalizes with microtubule. Used to study brain disease (multiple); cognitive disorder (multiple); obesity; and tauopathy (multiple). Biomarker of middle cerebral artery infarction. Human ortholog(s) of this gene implicated in dementia (multiple); neurodegenerative disease (multiple); progressive supranuclear palsy; and temporal lobe epilepsy. Orthologous to human MAPT (microtubule associated protein tau). [provided by Alliance of Genome Resources, Apr 2022]

Mapt Products (1)

mRNA Protein Name
NM_017212.3 NP_058908.2 microtubule-associated protein tau

Mapt Protein Structure

PRK10263

PRK10263: cl35903 (33 - 263)

PHA03247

PHA03247: cl33720 (220 - 590)

Tubulin-binding

Tubulin-binding: pfam00418 (603 - 632)

Tubulin-binding

Tubulin-binding: pfam00418 (634 - 663)

Tubulin-binding

Tubulin-binding: pfam00418 (665 - 695)

  • 0
  • 200
  • 400
  • 600
  • 770 a.a.
Protein Preferred Names Protein Names

microtubule-associated protein tau

  • PHF-tau

  • Tau microtubule-associated protein

  • microtubule-associated protein tau 0N4R

  • neurofibrillary tangle protein

  • paired helical filament-tau

Recombinant Mapt Proteins

Cat. No. Product Name Accession Purity
HY-P71753 Tau-A/SC1 Protein, Rat (P.pastoris, His) P19332-1 (A2-L752) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P700424 Tau-A/SC1 Protein, Rat (HEK293, His) P19332-1 (A2-L752) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-132582 Diranersen Inhibitor 93.23% Phase 2
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P991373 APNmAb005 Inhibitor 97.64% Phase 1

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-132582C Diranersen sodium Inhibitor 91.82% Unkown
HY-P4808A PHF6 TFA Activator 99.45% Unkown
HY-P4808 PHF6 Activator 99.17% Unkown
HY-147149 BPN-15477 Modulator 99.92% Unkown
HY-RS08140 MAPT Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08141 Mapt Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174215 TAU-IN-3 Inhibitor / Unkown
HY-RS08142 Mapt Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mapt NCBI NCBI:4137