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Shh - sonic hedgehog signaling molecule Gene

Also Known as ShhNC

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 29499

Summary

Predicted to enable several functions, including laminin-1 binding activity; metal ion binding activity; and patched binding activity. Involved in several processes, including animal organ development; negative regulation of cell death; and nervous system development. Acts upstream of or within ventral spinal cord interneuron specification. Located in several cellular components, including membrane raft; neuronal cell body; and synaptic vesicle. Used to study Parkinsonism and myocardial infarction. Biomarker of several diseases, including VACTERL association; chronic kidney disease; esophageal atresia/tracheoesophageal fistula; ocular hypertension; and temporal lobe epilepsy. Human ortholog(s) of this gene implicated in several diseases, including Hirschsprung's disease; holoprosencephaly (multiple); hypoplastic or aplastic tibia with polydactyly; middle cerebral artery infarction; and polydactyly. Orthologous to human SHH (sonic Hedgehog signaling molecule). [provided by Alliance of Genome Resources, Apr 2022]

Shh Products (1)

mRNA	Protein	Name
NM_017221.1	NP_058917.1	sonic hedgehog protein precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19139721	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in commissural neuron axon guidance	IMP IMP: Inferred from mutant phenotype	19946319	RGD
involved in digestive tract mesoderm development	IDA IDA: Inferred from direct assay	9368764	RGD
involved in epithelial tube branching involved in lung morphogenesis	IEP IEP: Inferred from expression pattern	8769111	RGD
involved in fungiform papilla development	IMP IMP: Inferred from mutant phenotype	15581865	RGD
involved in fungiform papilla formation	IMP IMP: Inferred from mutant phenotype	15581865	RGD
involved in fungiform papilla morphogenesis	IMP IMP: Inferred from mutant phenotype	15581865	RGD
involved in liver regeneration	IEP IEP: Inferred from expression pattern	22790641	RGD
involved in male genitalia morphogenesis	IMP IMP: Inferred from mutant phenotype	12533405	RGD
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	16988214	RGD
involved in neural tube formation	IMP IMP: Inferred from mutant phenotype	8124714	RGD
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	9236238	RGD
involved in positive regulation of endothelial cell chemotaxis	IDA IDA: Inferred from direct assay	20052412	RGD
involved in positive regulation of neuroblast proliferation	IMP IMP: Inferred from mutant phenotype	12469128	RGD
involved in positive regulation of neuron differentiation	IMP IMP: Inferred from mutant phenotype	8124714	RGD
involved in positive regulation of neurotrophin production	IMP IMP: Inferred from mutant phenotype	23237228	RGD
involved in positive regulation of oligodendrocyte progenitor proliferation	IDA IDA: Inferred from direct assay	12237843	RGD
involved in positive regulation of penile erection	IMP IMP: Inferred from mutant phenotype	12533405	RGD
involved in positive regulation of photoreceptor cell differentiation	IDA IDA: Inferred from direct assay	9236238	RGD
involved in positive regulation of sprouting angiogenesis	IDA IDA: Inferred from direct assay	20052412	RGD
involved in prostate gland development	IEP IEP: Inferred from expression pattern	15328011	RGD
involved in regulation of cell population proliferation	IDA IDA: Inferred from direct assay	12417650	RGD
involved in regulation of epithelial cell differentiation	IEP IEP: Inferred from expression pattern	14651923	RGD
involved in response to axon injury	IMP IMP: Inferred from mutant phenotype	15356205	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	15328011	RGD
involved in response to ethanol	IDA IDA: Inferred from direct assay	19139721	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	18228117	RGD
involved in response to retinoic acid	IEP IEP: Inferred from expression pattern	10633866	RGD
acts upstream of or within spinal cord dorsal/ventral patterning	IDA IDA: Inferred from direct assay	9230312	RGD
involved in telencephalon regionalization	IMP IMP: Inferred from mutant phenotype	9811591	RGD
involved in tongue development	IMP IMP: Inferred from mutant phenotype	15581865	RGD
involved in tongue morphogenesis	IMP IMP: Inferred from mutant phenotype	15581865	RGD
acts upstream of or within ventral spinal cord interneuron specification	IDA IDA: Inferred from direct assay	9230312	RGD
involved in zona limitans intrathalamica formation	IDA IDA: Inferred from direct assay	25281935	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in axon	IDA IDA: Inferred from direct assay	21182949	RGD
located in dendrite	IDA IDA: Inferred from direct assay	21182949	RGD
located in extracellular space	IDA IDA: Inferred from direct assay	19139721	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	22446553	RGD
is active in hippocampal mossy fiber to CA3 synapse	IDA IDA: Inferred from direct assay	22446553	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	21182949	RGD
is active in postsynapse	IDA IDA: Inferred from direct assay	22446553	RGD
is active in presynapse	IDA IDA: Inferred from direct assay	22446553	RGD
located in synaptic vesicle	IDA IDA: Inferred from direct assay	28262835	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
sonic hedgehog protein	shh unprocessed N-terminal signaling and C-terminal autoprocessing domains sonic hedgehog homolog

Related Agents

Approval
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0508	Ornidazole	Inhibitor	99.49%	Unkown

Pre-clinical Phase

Bioactive Molecules (22)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100224	SANT-1		99.87%	Unkown
HY-100515	Robotnikinin	Inhibitor	98.98%	Unkown
HY-108439	Neurodazine	Activator	99.0%	Unkown
HY-158059	DS-1-38	Inhibitor	99.57%	Unkown
HY-P10875	HL2-m5	Inhibitor	98.06%	Unkown
HY-144881	(S)-HH2853	Inhibitor	/	Unkown
HY-123781A	RUSKI-201 dihydrochloride	Inhibitor	98.20%	Unkown
HY-145387	MRT-81	Antagonist	99.85%	Unkown
HY-116455	BRD-9526		/	Unkown
HY-147743	SMO-IN-1	Inhibitor	/	Unkown
HY-147744	AZD7254	Inhibitor	/	Unkown
HY-183335	SMO-IN-6		/	Unkown
HY-B0508S	Ornidazole-d5	Inhibitor	/	Unkown
HY-B0508S1	Ornidazole-13C2,15N2	Inhibitor	/	Unkown
HY-RS12865	SHH Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-120664	BRD50837	Inhibitor	/	Unkown
HY-123781	RUSKI-201	Inhibitor	/	Unkown
HY-164500	MC3629	Inhibitor	/	Unkown
HY-N0836A	Jervine hydriodide		/	Unkown
HY-N18954	Heparin disaccharide III-S trisodium	Inhibitor	/	Unkown
HY-RS16599	Shh Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23033	Shh Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Bioactive MoleculesInhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P992409	MEDI-5304	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Shh	NCBI	NCBI:6469
Mus musculus	Shh	NCBI	NCBI:20423