RBM15B - RNA binding motif protein 15B Gene

Also Known as OTT3; HsOTT3; HUMAGCGB

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 29890

About RBM15B

Cytogenetic location: 3p21.2 Genomic coordinates (GRCh38): 3:51,391,285-51,397,908 (from NCBI)

This gene has 1 transcript (splice variant), 225 orthologues and 7 paralogues.

Summary

Members of the SPEN (Split-end) family of proteins, including RBM15B, have repressor function in several signaling pathways and may bind to RNA through interaction with spliceosome components (Hiriart et al., 2005 [PubMed 16129689]).[supplied by OMIM, Feb 2009]

RBM15B Products (1)

mRNA	Protein	Name
NM_013286.5	NP_037418.3	putative RNA-binding protein 15B

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables RNA binding	IDA IDA: Inferred from direct assay	27602518	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16129689	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in RNA methylation	IDA IDA: Inferred from direct assay	27602518	GOA
involved in dosage compensation by inactivation of X chromosome	IDA IDA: Inferred from direct assay	27602518	GOA
NOT involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	16129689	GOA
NOT involved in nucleocytoplasmic transport	IDA IDA: Inferred from direct assay	16129689	GOA
involved in regulation of alternative mRNA splicing, via spliceosome	IDA IDA: Inferred from direct assay	16129689	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of RNA N6-methyladenosine methyltransferase complex	IDA IDA: Inferred from direct assay	27602518	GOA
located in nuclear envelope	IDA IDA: Inferred from direct assay	19586903	GOA
located in nuclear speck	IDA IDA: Inferred from direct assay	19586903	GOA
NOT located in nucleolus	IDA IDA: Inferred from direct assay	16129689	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	16129689	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RBM15B Protein Structure

RRM_1

SPOC

0
200
400
600
800
890 a.a.

Protein Preferred Names	Protein Names
putative RNA-binding protein 15B	chromosome 3p21.1 gene sequence

RBM15B Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RBM15B	Q8NDT2	NAV2	Homo sapiens	Q8IVL1	Y2H Prey Pooling	25416956
Intra	RBM15B	Q8NDT2	NAV2	Homo sapiens	Q8IVL1	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Wilms Tumor 1	Nephroblastoma Wilms Tumor WT1 Wilms' Tumor Bilateral Wilms Tumor Wilms Tumor, Type 1 Wilms Tumor, Somatic Adult Nephroblastoma Wt1 Disorder Renal Embryonic Tumor Adult Kidney Wilms Tumor Childhood Kidney Wilms Tumor Nonanaplastic Kidney Wilms Tumor

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11736	RBM15B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	RBM15B	VGNC	VGNC:45410
Mus musculus	RBM15B	MGD	MGI:1923598
Rattus norvegicus	RBM15B	RGD	RGD:1305937
Others	RBM15B	NCBI