Bmi1 - BMI1 proto-oncogene, polycomb ring finger Gene

Also Known as Pcgf4

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 307151

Summary

Predicted to enable several functions, including RING-like zinc finger domain binding activity; promoter-specific chromatin binding activity; and zinc ion binding activity. Involved in cellular response to dexamethasone stimulus and cellular response to interleukin-1. Predicted to be located in cytosol; heterochromatin; and nuclear body. Predicted to be part of PRC1 complex. Human ortholog(s) of this gene implicated in acute myeloid leukemia; colorectal carcinoma; and hepatocellular carcinoma. Orthologous to several human genes including COMMD3-BMI1 (COMMD3-BMI1 readthrough). [provided by Alliance of Genome Resources, Apr 2022]

Bmi1 Products (1)

mRNA Protein Name
NM_001107368.2 NP_001100838.1 polycomb complex protein BMI-1

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in cellular response to dexamethasone stimulus IEP
IEP: Inferred from expression pattern
21368868 RGD
involved in cellular response to interleukin-1 IEP
IEP: Inferred from expression pattern
22706317 RGD
involved in regulation of kidney development IEP
IEP: Inferred from expression pattern
18467665 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

polycomb complex protein BMI-1

  • B lymphoma Mo-MLV insertion region 1

  • Bmi1 polycomb ring finger oncogene

  • polycomb group ring finger 4

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-112041 Unesbulin Inhibitor 99.17% Phase 3

Pre-clinical Phase

Bioactive Molecules (10)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15888 PTC-209 Inhibitor 99.76% Unkown
HY-160924 MS147 Degrader 98.31% Unkown
HY-158239 MS181 Degrader 98.36% Unkown
HY-103696 PTC-028 Inhibitor 98.0% Unkown
HY-15888A PTC-209 hydrobromide Inhibitor 99.02% Unkown
HY-172617 APD-94 Inhibitor / Unkown
HY-N0992 1,6,7-Trihydroxyxanthone Inhibitor / Unkown
HY-143655 QW24 Inhibitor / Unkown
HY-143658 SH498 Inhibitor / Unkown
HY-183634 BMI1/RING1B ligand-1 / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bmi1 NCBI NCBI:648