Uba1 - ubiquitin-like modifier activating enzyme 1 Gene

Also Known as Ube1x

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 314432

Summary

Predicted to enable ubiquitin activating enzyme activity. Predicted to be involved in cellular response to DNA damage stimulus; protein ubiquitination; and ubiquitin-dependent protein catabolic process. Predicted to be located in mitochondrion and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Predicted to colocalize with bounding membrane of organelle; desmosome; and heterochromatin. Human ortholog(s) of this gene implicated in VEXAS syndrome and X-linked spinal muscular atrophy 2. Orthologous to human UBA1 (ubiquitin like modifier activating enzyme 1). [provided by Alliance of Genome Resources, Apr 2022]

Uba1 Products (2)

mRNA Protein Name
NM_001014080.1 NP_001014102.1 ubiquitin-like modifier-activating enzyme 1
NM_001014080.1 NP_001014102.1 ubiquitin-like modifier-activating enzyme 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
16227972 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ubiquitin-like modifier-activating enzyme 1

  • ubiquitin-activating enzyme E1, Chr X

Uba1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Cross
Uba1 Q5U300 GAN Homo sapiens Q9H2C0
Anti Bait CoIP
16227972
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit Effect
Pureté Phase
HY-100487 TAK-243 99.86% Phase 1

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-13297 PYZD-4409 Inhibitor 98.0% Unkown
HY-103436 NSC624206 Inhibitor 99.0% Unkown
HY-RS24221 Uba1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15319 UBA1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17754 Uba1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19646 Uba2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Uba1 NCBI NCBI:7317