S1pr4 - sphingosine-1-phosphate receptor 4 Gene

Also Known as Edg6

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 314649

About S1pr4

Primary_assembly 7: 8,208,098-8,211,893 forward strand.mRatBN7.2:CM026980.1

This gene has 1 transcript (splice variant), 176 orthologues, 18 paralogues and is associated with 2 phenotypes.

Summary

Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and regulation of metabolic process. Predicted to be located in mitochondrion. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human S1PR4 (sphingosine-1-phosphate receptor 4). [provided by Alliance of Genome Resources, Apr 2022]

S1pr4 Products (1)

mRNA Protein Name
NM_001108075.1 NP_001101545.1 sphingosine 1-phosphate receptor 4

S1pr4 Protein Structure

7tm_GPCRs

7tm_GPCRs: cl28897 (76 - 346)

7tm_GPCRs

7tm_GPCRs: cd14964 (78 - 102)

7tm_GPCRs

7tm_GPCRs: cd14964 (111 - 132)

7tm_GPCRs

7tm_GPCRs: cd14964 (148 - 170)

7tm_GPCRs

7tm_GPCRs: cd14964 (192 - 208)

7tm_GPCRs

7tm_GPCRs: cd14964 (229 - 252)

7tm_GPCRs

7tm_GPCRs: cd14964 (278 - 300)

7tm_GPCRs

7tm_GPCRs: cd14964 (314 - 339)

  • 0
  • 100
  • 200
  • 300
  • 413 a.a.
Protein Preferred Names Protein Names

sphingosine 1-phosphate receptor 4

  • endothelial differentiation, G-protein-coupled receptor 6

  • endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor 6

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-12355 Siponimod Agonist 99.95% Yes
HY-10569 Ponesimod Agonist 99.78% Yes
HY-12355A Siponimod hemifumarate Agonist 99.64% Yes

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-17606 Cenerimod Agonist 99.43% Phase 3

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-136462 CYM50358 Antagonist 98.33% Unkown
HY-111253 CYM-5478 Agonist 99.90% Unkown
HY-176533 S1PR5-IN-1 Inhibitor 99.58% Unkown
HY-116146 CYM50179 Agonist 96.06% Unkown
HY-W040167 VPC 23153 Agonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens S1pr4 NCBI NCBI:8698