S1PR4 - sphingosine-1-phosphate receptor 4 Gene

Also Known as EDG6; LPC1; S1P4; SLP4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8698

About S1PR4

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:3,178,769-3,180,332 (from NCBI)

This gene has 2 transcripts (splice variants), 176 orthologues and 18 paralogues.

Summary

This gene is a member of the endothelial differentiation, G-protein-coupled (EDG)) receptor gene family. EDG receptors bind lysophospholipids or lysosphingolipids as ligands, and are involved in cell signalling in many different cell types. This EDG receptor gene is intronless and is specifically expressed in the lymphoid tissue. [provided by RefSeq, Jul 2008]

S1PR4 Products (1)

mRNA Protein Name
NM_003775.4 NP_003766.1 sphingosine 1-phosphate receptor 4 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

S1PR4 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (63 - 307)

  • 0
  • 100
  • 200
  • 300
  • 384 a.a.
Protein Preferred Names Protein Names

sphingosine 1-phosphate receptor 4

  • S1P receptor 4

  • S1P receptor Edg-6

  • endothelial differentiation G-protein coupled receptor 6

  • endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 6

  • sphingosine 1-phosphate receptor Edg-6

S1PR4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
S1PR4 O95977 GEMIN4 Homo sapiens P57678
Y2H Prey Pooling
32296183
Intra
S1PR4 O95977 GEMIN4 Homo sapiens P57678
Validated Y2H
32296183
Intra
S1PR4 O95977 GEMIN4 Homo sapiens P57678
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

S1PR4 Antibodies

Cat. No. Product Name Application Reactivity
HY-P80967 S1PR4 Antibody WB, IHC-P Rat

Related Diseases

Diseases Alias
Dermatitis, Atopic, 7

  • ATOD7

  • Dermatitis, Atopic, Susceptibility To, 7

  • Atopic Dermatitis 7

  • Dermatitis, Atopic 7
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-12355 Siponimod Agonist 99.95% Yes
HY-10569 Ponesimod Agonist 99.78% Yes
HY-12355A Siponimod hemifumarate Agonist 99.85% Yes

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-17606 Cenerimod Agonist 99.43% Phase 3

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-136462 CYM50358 Antagonist 98.33% Unkown
HY-111253 CYM-5478 Agonist 99.90% Unkown
HY-176533 S1PR5-IN-1 Inhibitor 99.58% Unkown
HY-116146 CYM50179 Agonist 96.06% Unkown
HY-W040167 VPC 23153 Agonist / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris S1PR4 VGNC VGNC:110551
Rattus norvegicus S1PR4 RGD RGD:1304801
Felis catus S1PR4 VGNC VGNC:64848
Mus musculus S1PR4 MGD MGI:1333809
Bos taurus S1PR4 VGNC VGNC:34255
Others S1PR4 NCBI