2. Gene
  3. S1PR4 - sphingosine-1-phosphate receptor 4 Gene

S1PR4 - sphingosine-1-phosphate receptor 4 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as EDG6; LPC1; S1P4; SLP4

Gene ID: 8698 | Gene type: protein coding

About S1PR4

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:3,178,769-3,180,332 (from NCBI)

This gene has 2 transcripts (splice variants), 176 orthologues and 18 paralogues.

Summary

This gene is a member of the endothelial differentiation, G-protein-coupled (EDG)) receptor gene family. EDG receptors bind lysophospholipids or lysosphingolipids as ligands, and are involved in cell signalling in many different cell types. This EDG receptor gene is intronless and is specifically expressed in the lymphoid tissue. [provided by RefSeq, Jul 2008]

S1PR4 Products(1)

mRNA Protein Name
NM_003775.4 NP_003766.1 sphingosine 1-phosphate receptor 4 precursor

S1PR4 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (63 - 307)

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  • 384 a.a.
Protein Preferred Names Protein Names

sphingosine 1-phosphate receptor 4

S1P receptor 4

S1P receptor Edg-6

endothelial differentiation G-protein coupled receptor 6

endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 6

sphingosine 1-phosphate receptor Edg-6

Related Diseases

Diseases Alias
Dermatitis, Atopic, 7

ATOD7

Dermatitis, Atopic, Susceptibility To, 7

Atopic Dermatitis 7

Dermatitis, Atopic 7
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Approval
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-12355 Siponimod Agonist 98.88% Yes
HY-10569 Ponesimod Agonist 99.81% Yes
HY-12355A Siponimod hemifumarate Agonist / Unkown
Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-17606 Cenerimod Agonist 99.43% Phase 3
Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-136462 CYM50358 Antagonist 98.04% Unkown
HY-116146 CYM50179 Agonist 95.01% Unkown
HY-111253 CYM-5478 Agonist / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris S1PR4 VGNC VGNC:110551
Rattus norvegicus S1PR4 RGD RGD:1304801
Felis catus S1PR4 VGNC VGNC:64848
Mus musculus S1PR4 MGD MGI:1333809
Bos taurus S1PR4 VGNC VGNC:34255