Sik2 - salt-inducible kinase 2 Gene

Also Known as Snf1lk2; RGD1559698

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 315649

About Sik2

Primary_assembly 8: 51,225,543-51,325,415 reverse strand.mRatBN7.2:CM026981.1

This gene has 3 transcripts (splice variants), 231 orthologues, 26 paralogues and is associated with 6 phenotypes. Biased expression in Thymus (RPKM 133.9), Kidney (RPKM 128.4) and 9 other tissues.

Summary

Predicted to enable ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction; protein autophosphorylation; and regulation of Insulin Receptor signaling pathway. Predicted to act upstream of or within Insulin Receptor signaling pathway and protein phosphorylation. Predicted to be located in cytoplasm and nucleus. Orthologous to human SIK2 (salt inducible kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Sik2 Products (1)

mRNA Protein Name
DQ188032.1 ABA28749.1 salt-inducible kinase 2
Protein Preferred Names Protein Names

  • salt-inducible kinase 2

  • SNF1-like kinase 2

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-157442 GLPG3312 Inhibitor 98.63% Phase 1

Pre-clinical Phase

Bioactive Molecules (16)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15776 HG-9-91-01 Inhibitor 99.77% Unkown
HY-120877 MRT199665 Inhibitor 99.85% Unkown
HY-120856 ARN-3236 Inhibitor 99.66% Unkown
HY-148061 DB1113 99.86% Unkown
HY-148062 RSS0680 98.03% Unkown
HY-139253 MRIA9 Inhibitor 98.88% Unkown
HY-175479 GLPG4970 Inhibitor 99.60% Unkown
HY-163743 SIC-19 Inhibitor 98.00% Unkown
HY-148063 DB0614 96.07% Unkown
HY-173191 SK-124 Inhibitor / Unkown
HY-171591 SIK2-IN-4 Inhibitor 99.06% Unkown
HY-164534 SIK2/3-IN-2 Inhibitor / Unkown
HY-171590 SIK2-IN-3 Inhibitor / Unkown
HY-170237 SIK2/3-IN-1 Inhibitor / Unkown
HY-182804 SIK2/3-IN-3 Inhibitor / Unkown
HY-178014 SIK1-IN-1 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sik2 NCBI NCBI:23235