Fus - Fus RNA binding protein Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 317385

Summary

Enables ionotropic glutamate receptor binding activity; Myosin V binding activity; and nuclear receptor binding activity. Involved in cellular response to calcium ion. Located in dendritic spine head; perikaryon; and perinuclear region of cytoplasm. Part of polysome. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; amyotrophic lateral sclerosis type 6; essential tremor 4; liposarcoma; and neurodegenerative disease. Orthologous to human FUS (FUS RNA binding protein). [provided by Alliance of Genome Resources, Apr 2022]

Fus Products (1)

mRNA Protein Name
NM_001012137.1 NP_001012137.1 RNA-binding protein FUS

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ionotropic glutamate receptor binding IPI
IPI: Inferred from physical interaction
19103256 RGD
enables myosin V binding IPI
IPI: Inferred from physical interaction
19103256 RGD
enables nuclear estrogen receptor binding IDA
IDA: Inferred from direct assay
9440806 RGD
enables nuclear retinoid X receptor binding IPI
IPI: Inferred from physical interaction
9440806 RGD
enables nuclear thyroid hormone receptor binding IDA
IDA: Inferred from direct assay
9440806 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to calcium ion IDA
IDA: Inferred from direct assay
19103256 RGD
Cellular Component GO Annotation Evidence References Source
located in dendrite IDA
IDA: Inferred from direct assay
15843054 RGD
located in dendritic spine IDA
IDA: Inferred from direct assay
15843054 RGD
located in dendritic spine head IDA
IDA: Inferred from direct assay
15843054 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
26834559 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
15843054 RGD
located in perikaryon IDA
IDA: Inferred from direct assay
15843054 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
15843054 RGD
is active in presynaptic cytosol IDA
IDA: Inferred from direct assay
26834559 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

RNA-binding protein FUS

  • 16) in malignant liposarcoma)

  • 16) malignant liposarcoma

  • fused in sarcoma RNA binding protein

  • fusion (involved in t(12

  • fusion, derived from t(12

  • fusion, derived from t(12

  • 16) malignant liposarcoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-147410 Ulefnersen 99.22% Phase 3

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P10580 Vasculotide Activator 99.84% Unkown
HY-P10580A Vasculotide TFA Activator 99.88% Unkown
HY-147410A Ulefnersen sodium 98.47% Unkown
HY-RS05149 FUS Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17359 Fus Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23813 Fus Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fus NCBI NCBI:2521