Sctr - secretin receptor Gene

Also Known as 6530402O03Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 319229

About Sctr

Chromosome 1: 119,934,624-119,991,266 forward strand.GRCm39:CM000994.3

This gene has 2 transcripts (splice variants), 130 orthologues, 41 paralogues and is associated with 30 phenotypes. Biased expression in stomach adult (RPKM 11.4), adrenal adult (RPKM 3.1) and 3 other tissues.

Summary

Enables Secretin Receptor activity. Involved in several processes, including diet induced thermogenesis; positive regulation of cAMP-mediated signaling; and water homeostasis. Predicted to be located in cytoplasmic microtubule. Predicted to be active in plasma membrane. Orthologous to human SCTR (Secretin Receptor). [provided by Alliance of Genome Resources, Apr 2022]

Sctr Products (2)

mRNA Protein Name
NM_001311077.1 NP_001298006.1 secretin receptor isoform 2 precursor
NM_001012322.2 NP_001012322.2 secretin receptor isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables secretin receptor activity IDA
IDA: Inferred from direct assay
30449620 MGI
Biological Process GO Annotation Evidence References Source
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
30449620 MGI
involved in diet induced thermogenesis IDA
IDA: Inferred from direct assay
30449620 MGI
involved in intracellular water homeostasis IMP
IMP: Inferred from mutant phenotype
17283064 MGI
involved in positive regulation of lipid catabolic process IDA
IDA: Inferred from direct assay
30449620 MGI
involved in positive regulation of lipid catabolic process IMP
IMP: Inferred from mutant phenotype
24273196 MGI
involved in regulation of appetite IDA
IDA: Inferred from direct assay
30449620 MGI
involved in regulation of appetite IMP
IMP: Inferred from mutant phenotype
20927047 MGI
involved in regulation of synaptic plasticity IMP
IMP: Inferred from mutant phenotype
17008357 MGI
involved in renal water absorption IMP
IMP: Inferred from mutant phenotype
17283064 MGI
involved in response to nutrient levels IDA
IDA: Inferred from direct assay
30449620 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Sctr Protein Structure

HRM

HRM: pfam02793 (76 - 139)

7tmB1_secretin

7tmB1_secretin: cd15275 (152 - 418)

7tmB1_secretin

7tmB1_secretin: cd15275 (154 - 179)

7tmB1_secretin

7tmB1_secretin: cd15275 (188 - 210)

7tmB1_secretin

7tmB1_secretin: cd15275 (229 - 256)

7tmB1_secretin

7tmB1_secretin: cd15275 (268 - 288)

7tmB1_secretin

7tmB1_secretin: cd15275 (304 - 333)

7tmB1_secretin

7tmB1_secretin: cd15275 (349 - 376)

7tmB1_secretin

7tmB1_secretin: cd15275 (380 - 405)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 464 a.a.
Protein Preferred Names Protein Names

secretin receptor

  • SCT-R

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12568 SCTR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-P11262 GUB021794 Agonist / Unkown
HY-RS12569 Sctr Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12570 Sctr Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sctr NCBI NCBI:6344