SCTR - secretin receptor Gene

Homo sapiens

Also known as SR

Gene ID: 6344 | Gene type: protein coding

About SCTR

Cytogenetic location: 2q14.2 Genomic coordinates (GRCh38): 2:119,439,843-119,524,483 (from NCBI)

This gene has 5 transcripts (splice variants), 130 orthologues and 42 paralogues. Biased expression in duodenum (RPKM 6.3), pancreas (RPKM 4.3) and 5 other tissues.

Summary

The protein encoded by this gene is a G protein-coupled receptor and belongs to the glucagon-VIP-secretin receptor family. It binds secretin which is the most potent regulator of pancreatic bicarbonate, electrolyte and volume secretion. Secretin and its receptor are suggested to be involved in pancreatic Cancer and autism. [provided by RefSeq, Jul 2008]

SCTR Products(13)

mRNA	Protein	Name
NM_002980.3	NP_002971.2	secretin receptor precursor
XM_011511621.3	XP_011509923.1	secretin receptor isoform X3
XR_007079571.1
XR_922984.3
XM_047445399.1	XP_047301355.1	secretin receptor isoform X1
XM_047445403.1	XP_047301359.1	secretin receptor isoform X7
XM_047445402.1	XP_047301358.1	secretin receptor isoform X6
XR_001738888.2
XR_001738889.2
XM_047445401.1	XP_047301357.1	secretin receptor isoform X5
XM_047445400.1	XP_047301356.1	secretin receptor isoform X2
XM_047445404.1	XP_047301360.1	secretin receptor isoform X8
XM_017004670.2	XP_016860159.2	secretin receptor isoform X4

SCTR Protein Structure

HRM

7tm_2

0
100
200
300
400
440 a.a.

Protein Preferred Names

Protein Names

secretin receptor

pancreatic secretin receptor

Related Diseases

Diseases

Alias

Isolated Growth Hormone Deficiency, Type Ib

Isolated Growth Hormone Deficiency Type Ib	IGHD1B
Ighd Ib	Growth Hormone Deficiency, Isolated, Type Ib
Congenital Ighd Type Ib	Congenital Isolated Gh Deficiency Type Ib
Congenital Isolated Growth Hormone Deficiency Type Ib	Dwarfism Of Sindh
Pituitary Dwarfism I	Isolated Growth Hormone Deficiency Type 1b
Ighd 1b	Growth Hormone Deficiency, Isolated, 1b

Cystic Fibrosis

Mucoviscidosis	CF
Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis	Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis
Cystic Fibrosis Lung Disease, Modifier Of	Cystic Fibrosis Of Pancreas
Fibrocystic Disease Of Pancreas	Cf - [Cystic Fibrosis]
Cystic Fibrosis Nos	Fibrocystic Disease
Fibrocystic Disease Of The Pancreas	Mucoviscidosis Of Pancreas
Nonproliferative Fibrocystic Disease	Pancreatic Cystic Fibrosis

Retinitis Pigmentosa 18

RP18	Retinitis Pigmentosa-18
Retinitis Pigmentosa, Type 18

Pancreas Disease

Abnormality Of The Pancreas

Pancreatic Diseases

X-Linked Nephrogenic Diabetes Insipidus

Nephrogenic Diabetes Insipidus Type 1

Doid:0081060

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Gastrinoma

Gastrin Cell Tumour	Gastrin Secreting Tumor
Malignant Gastrinoma	Gastrinoma, Malignant

Metaphyseal Chondrodysplasia, Jansen Type

Metaphyseal Chondrodysplasia, Murk Jansen Type	MCDJ
Jansen'S Metaphyseal Chondrodysplasia	Murk Jansen Type Metaphyseal Chondrodysplasia
Jansen Type Metaphyseal Chondrodysplasia	Jansen Disease
Jansen Metaphyseal Chondrodysplasia	Jansen Metaphyseal Dysostosis
Metaphyseal Chondrodysplasia Murk Jansen Type	Chondrodysplasia, Metaphyseal, Murk Jansen Type

Polycystic Liver Disease

Autosomal Dominant Polycystic Liver Disease	Isolated Polycystic Liver Disease
Pcld	Congenital Cystic Liver Disease
Congenital Hepatic Cyst	Fibrocystic Liver Disease
Isolated Autosomal Dominant Polycystic Liver Disease	Adpcld
Liver Disease, Polycystic	Multiple Cysts Of Liver
Pld - [Polycystic Liver Disease]	Polycystic Liver Disorder
Polycystic Liver	Congenital Polycystic Disease Of Liver
Congenital Polycystic Liver Disease

Suppurative Cholangitis

Pancreatic Cancer

Pancreatic Carcinoma	Familial Pancreatic Carcinoma
Pancreatic Neoplasm	Carcinoma Of Pancreas
Pancreatic Carcinoma, Familial	Malignant Neoplasm Of Pancreas
Pancreatic Acinar Carcinoma	Pancreatic Tumor
Familial Pancreatic Cancer	Neoplasm Of The Pancreas
Pancreatic Carcinoma, Somatic	Pancreatic Cancer, Somatic
Ca Body Of Pancreas	Ca Head Of Pancreas
Ca Tail Of Pancreas	Malignant Neoplasm Of Body Of Pancreas
Malignant Neoplasm Of Head Of Pancreas	Malignant Neoplasm Of Tail Of Pancreas
Pancreas Neoplasm	Exocrine Cancer
Exocrine Pancreas Carcinoma	Hereditary Pancreatic Cancer
Hereditary Pancreatic Carcinoma	PNCA
Cancer Of The Pancreas	Pancreatic Cancer, Susceptibility To
Carcinoma Of Head Of Pancreas	Pancreatic Neoplasms
Pancreatic Tumors	Cancer, Pancreatic
Cancer Of Pancreas	Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Jejunal Somatostatinoma

Jejunal Delta Cell Somatostatin Producing Tumor	Somatosatinoma Of Jejunum
Jejunal Somatostatin-Producing Neuroendocrine Tumor

Cholangitis, Primary Sclerosing

Primary Sclerosing Cholangitis	PSC
Sclerosing Cholangitis	Cholangitis, Sclerosing
Cholangitis Primary Sclerosing	Psc - [Primary Sclerosing Cholangitis]

Chondrodysplasia, Blomstrand Type

Chondrodysplasia Blomstrand Type	BOCD
Blomstrand Lethal Chondrodysplasia	Blomstrand Lethal Osteochondrodysplasia
Blomstrand'S Lethal Chondrodysplasia	Blc
Blomstrand Chondrodysplasia	Blomstrand Osteochondrodysplasia

Esophageal Adenosquamous Carcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-RS12568	SCTR Human Pre-designed siRNA Set A	/	Unkown
HY-RS12569	Sctr Mouse Pre-designed siRNA Set A	/	Unkown
HY-RS12570	Sctr Rat Pre-designed siRNA Set A	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SCTR	VGNC	VGNC:34370
Macaca mulatta	SCTR	VGNC	VGNC:76996
Felis catus	SCTR	VGNC	VGNC:64937
Mus musculus	SCTR	MGD	MGI:2441720
Rattus norvegicus	SCTR	RGD	RGD:621342
Canis familiaris	SCTR	VGNC	VGNC:45934

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