HRC - histidine rich calcium binding protein Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3270

About HRC

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:49,151,198-49,155,396 (from NCBI)

This gene has 4 transcripts (splice variants) and 87 orthologues. Restricted expression toward heart (RPKM 206.9).

Summary

This gene encodes a luminal sarcoplasmic reticulum protein identified by its ability to bind low-density lipoprotein with high affinity. The protein interacts with the cytoplasmic domain of triadin, the main transmembrane protein of the junctional sarcoplasmic reticulum (SR) of skeletal muscle. The protein functions in the regulation of releasable calcium into the SR. [provided by RefSeq, Sep 2008]

HRC Products (1)

mRNA Protein Name
NM_002152.3 NP_002143.1 sarcoplasmic reticulum histidine-rich calcium-binding protein precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATPase binding IPI
IPI: Inferred from physical interaction
17526652 GOA
enables calcium ion binding IDA
IDA: Inferred from direct assay
24125847 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17526652 GOA
enables transmembrane transporter binding IPI
IPI: Inferred from physical interaction
17526652 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of heart contraction IGI
IGI: Inferred from genetic interaction
24125847 GOA
involved in positive regulation of heart rate IGI
IGI: Inferred from genetic interaction
24125847 GOA
involved in positive regulation of relaxation of cardiac muscle IGI
IGI: Inferred from genetic interaction
24125847 GOA
involved in regulation of calcium ion transmembrane transport IGI
IGI: Inferred from genetic interaction
24125847 GOA
involved in regulation of cell communication by electrical coupling involved in cardiac conduction IGI
IGI: Inferred from genetic interaction
24125847 GOA
involved in regulation of cytosolic calcium ion concentration IGI
IGI: Inferred from genetic interaction
24125847 GOA
involved in regulation of heart rate IMP
IMP: Inferred from mutant phenotype
18617481 GOA
involved in regulation of peptidyl-serine phosphorylation IGI
IGI: Inferred from genetic interaction
24125847 GOA
involved in regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IGI
IGI: Inferred from genetic interaction
24125847 GOA
involved in regulation of ryanodine-sensitive calcium-release channel activity IGI
IGI: Inferred from genetic interaction
24125847 GOA
Cellular Component GO Annotation Evidence References Source
located in Z disc IDA
IDA: Inferred from direct assay
24125847 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HRC Protein Structure

Hist_rich_Ca-bd

Hist_rich_Ca-bd: Histidine-rich Calcium-binding repeat region (214 - 228)

Hist_rich_Ca-bd

Hist_rich_Ca-bd: Histidine-rich Calcium-binding repeat region (238 - 252)

Hist_rich_Ca-bd

Hist_rich_Ca-bd: Histidine-rich Calcium-binding repeat region (271 - 285)

Hist_rich_Ca-bd

Hist_rich_Ca-bd: Histidine-rich Calcium-binding repeat region (295 - 309)

Hist_rich_Ca-bd

Hist_rich_Ca-bd: Histidine-rich Calcium-binding repeat region (319 - 328)

Hist_rich_Ca-bd

Hist_rich_Ca-bd: Histidine-rich Calcium-binding repeat region (343 - 356)

  • 0
  • 200
  • 400
  • 600
  • 699 a.a.
Protein Preferred Names Protein Names

sarcoplasmic reticulum histidine-rich calcium-binding protein

HRC Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
HRC P23327 ZNF699 Homo sapiens Q32M78
Y2H Prey Pooling
32296183
Intra
HRC P23327 ZNF699 Homo sapiens Q32M78
Y2H Array
32296183
Intra
HRC P23327 ZNF699 Homo sapiens Q32M78
Validated Y2H
32296183
Cross
HRC P23327 Ryr2 Mus musculus E9Q401
Confocal
24805197
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Arrhythmogenic Right Ventricular Cardiomyopathy

  • Arrhythmogenic Right Ventricular Dysplasia

  • Arvc

  • Arvd

  • Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy

  • Arvc Cardiomyopathy

  • Arrhythmogenic Right Ventricular Cardiomyopathy-Dysplasia

  • Arvd/C

  • Right Ventricular Dysplasia, Arrhythmogenic

  • Ventricular Dysplasia, Right, Arrhythmogenic

  • Cardiomyopathy, Ventricular, Right, Arrhythmogenic

  • Dysplasia, Arrhythmogenic Right Ventricular
Type 2 Diabetes Mellitus

  • Insulin Resistance

  • NIDDM

  • Type 2 Diabetes

  • Diabetes Mellitus, Non-Insulin-Dependent

  • T2D

  • Noninsulin-Dependent Diabetes Mellitus

  • Diabetes Mellitus, Type Ii

  • Maturity-Onset Diabetes

  • Insulin Resistance, Severe, Digenic

  • Diabetes Mellitus, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent

  • Diabetes Mellitus, Noninsulin-Dependent, Association With

  • Diabetes Mellitus, Noninsulin-Dependent, Late Onset

  • Hypertension, Insulin Resistance-Related, Susceptibility To

  • Insulin Resistance, Susceptibility To

  • Non-Insulin-Dependent Diabetes Mellitus

  • Type Ii Diabetes Mellitus

  • Adult-Onset Diabetes Mellitus

  • Maturity-Onset Diabetes Mellitus

  • Diabetes Mellitus Type 2

  • Type Ii Diabetes

  • Type 2 Diabetes Mellitus, Susceptibility To

  • Diabetes, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Type 2, Susceptibility To

  • Diabetes Mellitus, Noninsulin-Dependent, 2

  • Diabetes Mellitus, Type Ii, Susceptibility To

  • Hypertension, Insulin Resistance-Related

  • Adult-Onset Diabetes

  • Aodm

  • Diabetes Mellitus, Adult-Onset

  • Diabetes Mellitus Type Ii

  • Diabetes Mellitus Type 2, Susceptibility To

  • Diabetes, Type Ii, Susceptibility To

  • Diabetes Type 2

  • Diabetes Mellitus

  • Adult Onset Diabetes

  • Maturity Onset Diabetes

  • Nonketotic Diabetes

  • Non-Insulin Dependent Diabetes Mellitus

  • T2dm - [Type 2 Diabetes Mellitus]

  • Niddm - [Non Insulin Dependent Diabetes Mellitus]

  • Dm2

  • Dm Type Ii

  • Diabetic Type 2

  • Insulin Requiring Type 2 Diabetes

  • Noninsulin Dependent Diabetes

  • Non-Insulin-Dependent Diabetes Mellitus Without Complications

  • Diabetes Due To Insulin Secretory Defect

  • Diabetes Mellitus Due To Insulin Secretory Defect

  • Non-Insulin-Dependent Diabetes Of The Young

  • Senile Diabetes

  • Nonketotic Hyperglycaemia

  • Stable Diabetes
Dilated Cardiomyopathy

  • Familial Dilated Cardiomyopathy

  • Primary Dilated Cardiomyopathy

  • Idiopathic Dilated Cardiomyopathy

  • Congestive Cardiomyopathy

  • Idiopathic Dilation Cardiomyopathy

  • Primary Familial Dilated Cardiomyopathy

  • Cardiomyopathy, Dilated

  • DCM

  • Cardiomyopathy, Familial Dilated

  • Dilated Cardiomyopathy, Familial

  • Hypokinetic Dilated Cardiomyopathy, Familial

  • Familial Idiopathic Cardiomyopathy

  • Fdc

  • Cardiomyopathy, Familial Idiopathic

  • Idiopathic Cardiomegaly

  • Dilated Congestive Cardiomyopathy

  • Chronic Dilated Cardiomyopathy

  • Ccm - [Congestive Cardiomyopathy]

  • Cocm - [Congestive Cardiomyopathy]

  • Dcm - [Dilated Cardiomyopathy]

  • Dilated-Hypokinetic Cardiomyopathy

  • Congestive Idiopathic Cardiomyopathy

  • Primary Idiopathic Dilated Cardiomyopathy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06357 HRC Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19109 Hrc Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25599 Hrc Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris HRC VGNC VGNC:41783
Bos taurus HRC VGNC VGNC:29952
Rattus norvegicus HRC RGD RGD:727864
Macaca mulatta HRC VGNC VGNC:73520
Mus musculus HRC MGD MGI:96226
Others HRC NCBI