MYLK4 - myosin light chain kinase family member 4 Gene

Also Known as SgK085

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 340156

About MYLK4

This gene has 4 transcripts (splice variants), 265 orthologues and 22 paralogues. Ubiquitous expression in kidney (RPKM 1.8), thyroid (RPKM 1.3) and 25 other tissues.

Summary

Predicted to enable Myosin light chain kinase activity. Predicted to be involved in protein phosphorylation. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

MYLK4 Products (2)

mRNA Protein Name
NM_001012418.5 NP_001012418.2 myosin light chain kinase family member 4 isoform 1
NM_001347872.2 NP_001334801.1 myosin light chain kinase family member 4 isoform 2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
22939624 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MYLK4 Protein Structure

Pkinase

Pkinase: Protein kinase domain (108 - 361)

  • 0
  • 100
  • 200
  • 300
  • 388 a.a.
Protein Preferred Names Protein Names

myosin light chain kinase family member 4

  • caMLCK like

MYLK4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MYLK4 Q86YV6 HSP90AB1 Homo sapiens P08238
Anti Tag CoIP
33961781
Intra
MYLK4 Q86YV6 HSP90AB1 Homo sapiens P08238
Anti Tag CoIP
28514442
Intra
MYLK4 Q86YV6 HSP90AB1 Homo sapiens P08238
Pull Down
32707033
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Deafness, Autosomal Recessive 14

  • DFNB14

  • Autosomal Recessive Nonsyndromic Deafness 14

  • Autosomal Recessive Deafness 14
Cardiomyopathy, Familial Restrictive, 2

  • RCM2

  • Restrictive Cardiomyopathy 2

  • Familial Restrictive Cardiomyopathy 2

  • Cardiomyopathy, Restrictive, Familial, Type 2
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-RS08926 MYLK4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22662 Mylk4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29176 Mylk4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta MYLK4 VGNC VGNC:75033
Mus musculus MYLK4 MGD MGI:3643758
Felis catus MYLK4 VGNC VGNC:102472
Rattus norvegicus MYLK4 RGD RGD:6494757
Bos taurus MYLK4 VGNC VGNC:31808
Others MYLK4 NCBI