IFNA2 - interferon alpha 2 Gene
Also Known as IFNA; IFNA2B; leIF A; IFN-alphaA; IFN-alpha-2
Species: Homo sapiens
About IFNA2
This gene has 1 transcript (splice variant), 580 orthologues and 16 paralogues.
Summary
This gene is a member of the alpha interferon gene cluster on chromosome 9. The encoded cytokine is a member of the type I interferon family that is produced in response to viral Infection as a key part of the innate immune response with potent Antiviral, antiproliferative and immunomodulatory properties. This cytokine, like Other type I interferons, binds a plasma membrane receptor made of IFNAR1 and IFNAR2 that is ubiquitously expressed, and thus is able to act on virtually all body cells. The encoded protein is effective in reducing the symptoms and duration of the common cold and in treating many types of Cancer, including some hematological malignancies and solid tumors. A deficiency of type I interferon in the blood is thought to be a hallmark of severe COVID-19 and may provide a rationale for a combined therapeutic approach. [provided by RefSeq, Aug 2020]
IFNA2 Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_000605.4 | NP_000596.2 | interferon alpha-2 precursor |
IFNA2 Protein Structure
Interferon: Interferon alpha/beta domain (26 - 185)
- 0
- 100
- 188 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
interferon alpha-2 |
|
IFNA2 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
IFNA2 | P01563 | TIMMDC1 | Homo sapiens | Q9NPL8 | 32296183 | |
|
Intra
|
IFNA2 | P01563 | TIMMDC1 | Homo sapiens | Q9NPL8 | 32296183 | |
|
Intra
|
IFNA2 | P01563 | TIMMDC1 | Homo sapiens | Q9NPL8 | 32296183 | |
|
Intra
|
IFNA2 | P01563 | IFNAR2 | Homo sapiens | P48551 | 21854986 |
Recombinant IFNA2 Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P7022 | IFN-alpha 2a/IFNA2 Protein, Human (R46K) | P01563 (C24-E188, R46K) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P7023 | IFN-alpha 2b/IFNA2 Protein, Human | P01563 (C24-E188) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P73246 | IFN-alpha 2b/IFNA2 Protein, Human (P.pastoris) | P01563-1 (C24-E188) | ≥ 90%, as determined by reducing SDS-PAGE. |
| HY-P78672 | IFN-alpha 2b/IFNA2 Protein, Human (HEK293, Fc) | P01563 (C24-E188) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P701095 | IFN-alpha 2b/IFNA2 Protein, Human (His) | P01563 (C24-E188) | ≥ 95%, as determined by reducing SDS-PAGE. |
IFNA2 Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P86927 | Interferon alpha 2 Antibody (YA6620) | WB, ICC/IF, IHC-P | Human |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Severe Covid-19 |
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| Hepatitis B |
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| Hepatitis |
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| Lymphomatoid Granulomatosis |
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| Hepatitis C |
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| Orchitis |
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| Cryoglobulinemia |
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| Hepatitis D |
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| Viral Hepatitis |
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| Polyarteritis Nodosa |
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| Kaposi Sarcoma |
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| Hemangioma-Thrombocytopenia Syndrome |
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| Conjunctival Cancer |
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| Peyronie Disease |
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| Systemic Mastocytosis |
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| Stomatitis |
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| Gorham'S Disease |
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| Hairy Cell Leukemia |
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| Corneal Intraepithelial Neoplasm |
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| Conjunctival Intraepithelial Neoplasm |
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| Conjunctival Squamous Cell Carcinoma |
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| Mastocytosis |
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| Conjunctival Pigmentation |
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| Common Cold |
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| Peyronie'S Disease |
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| Mycosis Fungoides |
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| Transitional Cell Carcinoma |
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| Cornea Cancer |
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| Geniculate Ganglionitis |
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| Uveitis |
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| Covid-19 |
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| Giant Hemangioma |
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| Neutropenia |
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| Dysentery |
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| Viral Infectious Disease |
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| Thrombocytopenic Purpura, Autoimmune |
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| Squamous Papillomatosis |
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| Hypereosinophilic Syndrome |
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| Panuveitis |
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| Pyoderma |
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| Penile Disease |
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| Herpes Zoster |
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| Vasculitis |
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| Myelofibrosis |
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| Splenomegaly |
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| Factor Vii Deficiency |
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| Thrombocytopenia |
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| Essential Thrombocythemia |
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| Angioma, Tufted |
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| Cryoglobulinemia, Familial Mixed |
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| Hypothyroidism |
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| Epithelioid Hemangioendothelioma |
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| Primary Cutaneous T-Cell Non-Hodgkin Lymphoma |
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| Carcinoid Syndrome |
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| Membranoproliferative Glomerulonephritis |
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| Vascular Cancer |
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| Leukemia, Chronic Myeloid |
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| Acquired Immunodeficiency Syndrome |
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| Liver Disease |
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| Hepatitis A |
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| Conjunctival Disease |
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| Discoid Lupus Erythematosus |
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| Malignant Conjunctival Melanoma |
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| Pyoderma Gangrenosum |
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| Malignant Skin Fibrous Histiocytoma |
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| Malignant Dermis Tumor |
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| Conjunctival Degeneration |
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| Gastroenteritis |
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| Behcet Syndrome |
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| Pinguecula |
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| Diarrhea |
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| Myeloproliferative Neoplasm |
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| Punctate Epithelial Keratoconjunctivitis |
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| Deficiency Anemia |
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| Mechanical Ectropion |
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| Polycythemia Vera |
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| Bladder Cancer |
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| Sezary'S Disease |
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| Colorectal Cancer |
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| Melanoma |
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| Serotonin Syndrome |
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| Focal Epithelial Hyperplasia |
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| Renal Cell Carcinoma, Nonpapillary |
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| Beach Ear |
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| Hemangioma |
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| Bladder Tuberculosis |
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| Kidney Cancer |
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| Polyneuropathy |
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| Anogenital Venereal Wart |
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| Internal Hordeolum |
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| Mucosal Melanoma |
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| Hepatocellular Carcinoma |
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| Hemolytic Anemia |
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| Cervix Melanoma |
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| Ocular Melanoma |
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| Malaria |
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| Systemic Lupus Erythematosus |
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| Micronodular Basal Cell Carcinoma |
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| Orbit Rhabdomyosarcoma |
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| Myelodysplastic Syndrome |
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| Myeloma, Multiple |
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| Aggressive Systemic Mastocytosis |
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| Melanoma, Cutaneous Malignant 1 |
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