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EVX2 - even-skipped homeobox 2 Gene

Also Known as EVX-2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 344191

About EVX2

Cytogenetic location: 2q31.1 Genomic coordinates (GRCh38): 2:176,077,472-176,083,962 (from NCBI)

This gene has 1 transcript (splice variant), 186 orthologues and 50 paralogues. Low expression observed in reference dataset.

Summary

This gene is located at the 5' end of the HOXD gene cluster on chromosome 2. The encoded protein is a homeobox transcription factor that is related to the protein encoded by the Drosophila even-skipped (eve) gene, a member of the pair-rule class of segmentation genes. A 117 kb microdeletion at the 5' end of the HOXD gene cluster, which includes this gene and the HOXD9-HOXD13 genes, causes synpolydactyly, a dominantly inherited disease resulting in limb malformation. [provided by RefSeq, Sep 2009]

EVX2 Products (1)

mRNA	Protein	Name
NM_001080458.2	NP_001073927.1	homeobox even-skipped homolog protein 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EVX2 Protein Structure

Homeobox

0
100
200
300
400
476 a.a.

Protein Preferred Names	Protein Names
homeobox even-skipped homolog protein 2	eve, even-skipped homeo box homolog 2

EVX2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	EVX2	Q03828	KRTAP19-7	Homo sapiens	Q3SYF9	Y2H Prey Pooling	32296183
Intra	EVX2	Q03828	KRTAP19-7	Homo sapiens	Q3SYF9	Validated Y2H	32296183
Intra	EVX2	Q03828	KRTAP19-7	Homo sapiens	Q3SYF9	Y2H Array	32296183
Intra	EVX2	Q03828	KRTAP19-5	Homo sapiens	Q3LI72	Validated Y2H	32296183
Intra	EVX2	Q03828	KRTAP19-5	Homo sapiens	Q3LI72	Y2H Array	32296183
Intra	EVX2	Q03828	KRTAP19-5	Homo sapiens	Q3LI72	Y2H Prey Pooling	32296183
Intra	EVX2	Q03828	BPIFB3	Homo sapiens	P59826	Y2H Prey Pooling	32296183
Intra	EVX2	Q03828	BPIFB3	Homo sapiens	P59826	Y2H Array	32296183
Intra	EVX2	Q03828	ITIH6	Homo sapiens	Q6UXX5	Y2H Prey Pooling	32296183
Intra	EVX2	Q03828	ITIH6	Homo sapiens	Q6UXX5	Validated Y2H	32296183
Intra	EVX2	Q03828	ITIH6	Homo sapiens	Q6UXX5	Y2H Array	32296183
Intra	EVX2	Q03828	ZMYND12	Homo sapiens	Q9H0C1	Y2H Prey Pooling	32296183
Intra	EVX2	Q03828	ZMYND12	Homo sapiens	Q9H0C1	Validated Y2H	32296183
Intra	EVX2	Q03828	ZMYND12	Homo sapiens	Q9H0C1	Y2H Array	32296183
Intra	EVX2	Q03828	KRTAP6-1	Homo sapiens	Q3LI64	Y2H Array	32296183
Intra	EVX2	Q03828	KRTAP6-1	Homo sapiens	Q3LI64	Y2H Prey Pooling	32296183
Intra	EVX2	Q03828	KRTAP6-1	Homo sapiens	Q3LI64	Validated Y2H	32296183
Intra	EVX2	Q03828	CNFN	Homo sapiens	Q9BYD5	Y2H Array	32296183
Intra	EVX2	Q03828	CNFN	Homo sapiens	Q9BYD5	Validated Y2H	32296183
Intra	EVX2	Q03828	CNFN	Homo sapiens	Q9BYD5	Y2H Prey Pooling	32296183
Intra	EVX2	Q03828	DMAC2L	Homo sapiens	Q99766-3	Y2H Prey Pooling	32296183
Intra	EVX2	Q03828	DMAC2L	Homo sapiens	Q99766-3	Validated Y2H	32296183
Intra	EVX2	Q03828	DMAC2L	Homo sapiens	Q99766-3	Y2H Array	32296183
Intra	EVX2	Q03828	LASP1	Homo sapiens	Q14847-2	Y2H Prey Pooling	32296183
Intra	EVX2	Q03828	LASP1	Homo sapiens	Q14847-2	Validated Y2H	32296183
Intra	EVX2	Q03828	LASP1	Homo sapiens	Q14847-2	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Synpolydactyly	Syndactyly Type 2 Syndactyly, Type 2 Spd
Split-Hand/Foot Malformation 6	Split Hand-Foot Malformation 6 SHFM6 Ectrodactyly, Autosomal Recessive Ectrodactyly Autosomal Recessive Split-Hand/Foot Malformation, Type 6
Split-Hand/Foot Malformation 5	Split Hand-Foot Malformation 5 SHFM5
Split-Hand/Foot Malformation 2	SHFM2 Shfd2 Shsf2 Split Hand/Foot Malformation 2 Split Hand-Foot Malformation 2 Split-Hand/Split-Foot Anomaly, X-Linked Split-Hand/Foot Deformity 2 Split Hand/Foot Malformation X-Linked Split Hand Foot Anomaly - X-Linked Split Hand Foot Deformity 2
Brachydactyly, Type A3	Brachydactyly Type A3 BDA3 Brachydactyly-Clinodactyly Brachymesophalangy V Brachymesophalangy 5 Brachydactyly Clinodactyly
Split-Hand/Foot Malformation 4	SHFM4 Split Hand-Foot Malformation 4 Split-Hand/Foot Malformation, Type 4
Split Hand-Foot Malformation	Ectrodactyly Split-Hand/Foot Malformation Lobster-Claw Deformity Split-Hand Deformity Split Hand Foot Malformation Shfm Split Hand Foot Deformity Split Hand Foot Deformity 1
Brachydactyly, Type D	Brachydactyly Type D BDD Stub Thumb Brachydactyly D
Chromosome 2q35 Duplication Syndrome	Syndactyly Syndactyly Type 1 Sdty1 Zygodactyly Syndactyly, Type I Sd1 Syndactyly, Type 1, With Or Without Craniosynostosis Symphalangism Non-Syndromic Syndactyly Symphalangy Webbing Of Digits Syndactyly, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04580	EVX2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	EVX2	VGNC	VGNC:106727
Rattus norvegicus	EVX2	RGD	RGD:1305594
Macaca mulatta	EVX2	VGNC	VGNC:104527
Felis catus	EVX2	VGNC	VGNC:61993
Canis familiaris	EVX2	VGNC	VGNC:40507
Mus musculus	EVX2	MGD	MGI:95462
Others	EVX2	NCBI