JCHAIN - joining chain of multimeric IgA and IgM Gene

Also Known as IGJ; JCH; IGCJ

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3512

About JCHAIN

Cytogenetic location: 4q13.3 Genomic coordinates (GRCh38): 4:70,655,541-70,666,508 (from NCBI)

This gene has 5 transcripts (splice variants) and 126 orthologues. Biased expression in colon (RPKM 2264.9), duodenum (RPKM 2014.1) and 10 other tissues.

Summary

Enables IgA binding activity and protein homodimerization activity. Contributes to several functions, including immunoglobulin receptor binding activity; peptidoglycan binding activity; and phosphatidylcholine binding activity. Involved in several processes, including defense response to Other organism; glomerular filtration; and positive regulation of respiratory burst. Located in extracellular space. Part of monomeric IgA immunoglobulin complex; pentameric IgM immunoglobulin complex; and secretory dimeric IgA immunoglobulin complex. [provided by Alliance of Genome Resources, Apr 2022]

JCHAIN Products (1)

mRNA	Protein	Name
NM_144646.4	NP_653247.1	immunoglobulin J chain precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables IgA binding	IMP IMP: Inferred from mutant phenotype	17237408	GOA
contributes to immunoglobulin receptor binding	IDA IDA: Inferred from direct assay	23250751	GOA
contributes to immunoglobulin receptor binding	IMP IMP: Inferred from mutant phenotype	17237408	GOA
contributes to peptidoglycan binding	IDA IDA: Inferred from direct assay	21786026	GOA
contributes to phosphatidylcholine binding	IDA IDA: Inferred from direct assay	21786026	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	21786026	GOA
contributes to single-stranded DNA binding	IDA IDA: Inferred from direct assay	21786026	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in adaptive immune response	IDA IDA: Inferred from direct assay	21786026	GOA
involved in antibacterial humoral response	IDA IDA: Inferred from direct assay	23250751	GOA
involved in glomerular filtration	IMP IMP: Inferred from mutant phenotype	23398317	GOA
involved in innate immune response	IDA IDA: Inferred from direct assay	21786026	GOA
involved in positive regulation of respiratory burst	IDA IDA: Inferred from direct assay	24145934	GOA
involved in protein-containing complex assembly	IMP IMP: Inferred from mutant phenotype	17237408	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of dimeric IgA immunoglobulin complex	IMP IMP: Inferred from mutant phenotype	17237408	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	23398317	GOA
NOT part of hexameric IgM immunoglobulin complex	IDA IDA: Inferred from direct assay	21786026	GOA
part of monomeric IgA immunoglobulin complex	IDA IDA: Inferred from direct assay	23250751	GOA
part of pentameric IgM immunoglobulin complex	IDA IDA: Inferred from direct assay	21786026	GOA
part of secretory IgA immunoglobulin complex	IDA IDA: Inferred from direct assay	23250751	GOA
part of secretory dimeric IgA immunoglobulin complex	IDA IDA: Inferred from direct assay	24145934	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

JCHAIN Protein Structure

Ig_J_chain

0
100
159 a.a.

Protein Preferred Names	Protein Names
immunoglobulin J chain	IgJ chain

Recombinant JCHAIN Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74842	IgJ Protein, Human (His)	P01591/NP_653247.1 (Q23-D159)	≥ 95%, as determined by reducing SDS-PAGE.

JCHAIN Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81473	IGJ Antibody (YA1218)	IHC-P	Human
HY-P81473A	IGJ Antibody (YA1218)(PBS only)	IHC-P	Human
HY-P81545	IGJ Antibody (YA1290)	WB, IHC-P, ICC/IF, FC	Human, Mouse

Related Diseases

Diseases	Alias
Alpha Chain Disease	Seligmann'S Disease Immunoproliferative Small Intestinal Disease
Mu Chain Disease	Mu-Chain Disease
Epiphyseal Chondrodysplasia, Miura Type	ECDM Tall Stature-Scoliosis-Macrodactyly Of The Great Toes Syndrome Miura Type Epiphyseal Chondrodysplasia Tall Stature-Scoliosis-Macrodactyly Of The Halluces Syndrome Tall Stature-Long Halluces-Multiple Extra-Epiphyses Syndrome Chondrodysplasia, Epiphyseal, Miura Type
Immunoglobulin Alpha Deficiency	Iga Deficiency Gamma-A-Globulin Deficiency Immunoglobulin A Deficiency
Hodgkin'S Lymphoma, Lymphocytic-Histiocytic Predominance	Hodgkin Disease Hodgkin Lymphoma, Lymphocyte-Rich Hodgkin Lymphoma, Lymphocytic-Histiocytic Predominance Hodgkin'S Disease, Lymphocyte Predominance Lymphocyte Rich Hodgkin'S Disease Lymphocyte Rich Classical Hodgkin Lymphoma
Heavy Chain Disease	Hcd
Ciliary Dyskinesia, Primary, 7	Primary Ciliary Dyskinesia 7 CILD7 Ciliary Dyskinesia, Primary, 7, With Or Without Situs Inversus Primary Ciliary Dyskinesia 7 With Or Without Situs Inversus Ics7 Immotile Cilia Syndrome 7 Dyskinesia, Ciliary, Primary, 7
Isolated Growth Hormone Deficiency	Congenital Ighd Congenital Isolated Gh Deficiency Congenital Isolated Growth Hormone Deficiency Non-Acquired Isolated Growth Hormone Deficiency Pituitary Dwarfism Dwarfism, Pituitary Isolated Somatotropin Deficiency Isolated Congenital Growth Hormone Deficiency Familial Isolated Growth Hormone Deficiency Ighd Dwarfism, Growth Hormone Deficiency Growth Hormone Deficiency Dwarfism Isolated Gh Deficiency Isolated Hgh Deficiency Isolated Human Growth Hormone Deficiency Isolated Somatotropin Deficiency Disorder Dwarfism Pituitary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P4062	Insulin peglispro		/	Phase 3

Pre-clinical Phase

Bioactive Molecules (15)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P3479	Insulin (swine)		99.90%	Unkown
HY-P3432	DfTat		99.53%	Unkown
HY-P4890A	Relaxin H3 (human) TFA		/	Unkown
HY-P10204	FZD7 antagonist 1		/	Unkown
HY-P10693	CZEN-002	Inhibitor	/	Unkown
HY-P11246	A13:B7-24-GG	Agonist	/	Unkown
HY-P11548	Rattusin	Inhibitor	/	Unkown
HY-P11625	R9-13	Activator	/	Unkown
HY-P11823	FAPα/DPP4 flurogenic substrate-1		/	Unkown
HY-P1371	Pseudo RACK1	Agonist	/	Unkown
HY-P1372	PKC ζ pseudosubstrate	Inhibitor	/	Unkown
HY-P4890	Relaxin H3 (human)		/	Unkown
HY-RS07033	JCHAIN Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17925	Jchain Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24395	Jchain Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	JCHAIN	VGNC	VGNC:106622
Canis familiaris	JCHAIN	VGNC	VGNC:42184
Rattus norvegicus	JCHAIN	RGD	RGD:1310155
Felis catus	JCHAIN	VGNC	VGNC:107339
Bos taurus	JCHAIN	VGNC	VGNC:30373
Mus musculus	JCHAIN	MGD	MGI:96493
Others	JCHAIN	NCBI