IPP - intracisternal A particle-promoted polypeptide Gene

Also Known as KLHL27

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3652

About IPP

Cytogenetic location: 1p34.1 Genomic coordinates (GRCh38): 1:45,694,324-45,750,653 (from NCBI)

This gene has 4 transcripts (splice variants), 195 orthologues and 54 paralogues. Ubiquitous expression in thyroid (RPKM 2.7), testis (RPKM 2.4) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the kelch family of proteins, which is characterized by a 50 amino acid repeat which interacts with actin. Transcript variants have been described but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]

IPP Products (2)

mRNA Protein Name
NM_001145349.2 NP_001138821.1 actin-binding protein IPP isoform 2
NM_005897.3 NP_005888.1 actin-binding protein IPP isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IPP Protein Structure

BTB

BTB: BTB/POZ domain (28 - 133)

BACK

BACK: BTB And C-terminal Kelch (139 - 240)

Kelch_1

Kelch_1: Kelch motif (289 - 329)

Kelch_1

Kelch_1: Kelch motif (332 - 377)

Kelch_1

Kelch_1: Kelch motif (379 - 423)

Kelch_1

Kelch_1: Kelch motif (427 - 471)

Kelch_1

Kelch_1: Kelch motif (474 - 519)

Kelch_1

Kelch_1: Kelch motif (522 - 572)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 584 a.a.
Protein Preferred Names Protein Names

actin-binding protein IPP

  • kelch-like family member 27

Related Diseases

Diseases Alias
Peroneal Nerve Paralysis

  • Peroneal Nerve Palsy
Progressive Myoclonus Epilepsy 10

  • Early-Onset Lafora Body Disease

  • Epm10
Villonodular Synovitis

  • Pigmented Villonodular Synovitis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-126404 Casein hydrolysate / Phase 4

Pre-clinical Phase

Bioactive Molecules (12)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-110063 4-IPP Inhibitor 99.40% Unkown
HY-Y1885 Tetrasodium pyrophosphate Inhibitor 99.60% Unkown
HY-130573A DMAPP triammonium Activator 95.0% Unkown
HY-105037A Forigerimod TFA Inhibitor 99.88% Unkown
HY-105037 Forigerimod Inhibitor / Unkown
HY-126825 NE21650 Inhibitor / Unkown
HY-130573 DMAPP / Unkown
HY-148969 FPPS-IN-1 / Unkown
HY-RS06873 IPP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-182347 LSPN954 Inhibitor / Unkown
HY-RS17395 Ipp Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23850 Ipp Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus IPP RGD RGD:1306299
Felis catus IPP VGNC VGNC:67816
Macaca mulatta IPP VGNC VGNC:73754
Canis familiaris IPP VGNC VGNC:42070
Bos taurus IPP VGNC VGNC:30247
Mus musculus IPP MGD MGI:96581
Others IPP NCBI