KRT77 - keratin 77 Gene

Also Known as K1B; KRT1B

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 374454

About KRT77

Cytogenetic location: 12q13.13 Genomic coordinates (GRCh38): 12:52,689,626-52,703,524 (from NCBI)

This gene has 3 transcripts (splice variants), 79 orthologues and 68 paralogues. Restricted expression toward skin (RPKM 121.1).

Summary

Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This gene encodes an epithelial keratin that is expressed in the skin and eccrine sweat glands. The type II keratins are clustered in a region of chromosome 12q13.[provided by RefSeq, Jun 2009]

KRT77 Products (1)

mRNA Protein Name
NM_175078.3 NP_778253.2 keratin, type II cytoskeletal 1b

KRT77 Protein Structure

Filament

Filament: Intermediate filament protein (163 - 476)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 578 a.a.
Protein Preferred Names Protein Names

keratin, type II cytoskeletal 1b

  • CK-1B

KRT77 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
KRT77 Q7Z794 KRT35 Homo sapiens Q92764
Y2H Array
32296183
Intra
KRT77 Q7Z794 KRT35 Homo sapiens Q92764
Y2H Prey Pooling
32296183
Intra
KRT77 Q7Z794 KRT35 Homo sapiens Q92764
Validated Y2H
32296183
Intra
KRT77 Q7Z794 KRT36 Homo sapiens O76013-2
Y2H Prey Pooling
32296183
Intra
KRT77 Q7Z794 KRT36 Homo sapiens O76013-2
Y2H Array
32296183
Intra
KRT77 Q7Z794 KRT27 Homo sapiens Q7Z3Y8
Y2H Array
32296183
Intra
KRT77 Q7Z794 KRT27 Homo sapiens Q7Z3Y8
Y2H Prey Pooling
32296183
Intra
KRT77 Q7Z794 MDFI Homo sapiens Q99750
Validated Y2H
32296183
Intra
KRT77 Q7Z794 MDFI Homo sapiens Q99750
Y2H Array
32296183
Intra
KRT77 Q7Z794 MDFI Homo sapiens Q99750
Y2H Prey Pooling
32296183
Intra
KRT77 Q7Z794 KRT15 Homo sapiens P19012
Y2H Prey Pooling
32296183
Intra
KRT77 Q7Z794 KRT15 Homo sapiens P19012
Y2H Array
32296183
Intra
KRT77 Q7Z794 KRT19 Homo sapiens P08727
Y2H Prey Pooling
32296183
Intra
KRT77 Q7Z794 KRT19 Homo sapiens P08727
Y2H Array
32296183
Intra
KRT77 Q7Z794 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
32296183
Intra
KRT77 Q7Z794 KRT31 Homo sapiens Q15323
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

KRT77 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81268 Cytokeratin 5 Antibody (YA953) WB Human, Mouse, Rat
HY-P83764 pan Cytokeratin Antibody(YA3563) WB, IHC-P, mIHC, ICC/IF, IF-Tissue, FC Human

Related Diseases

Diseases Alias
Aggressive Digital Papillary Adenocarcinoma
Macular Degeneration, Age-Related, 13

  • Age Related Macular Degeneration 13

  • ARMD13

  • Macular Degeneration, Age-Related, 13, Susceptibility To

  • Macular Degeneration, Age-Related, Type 13
Palmoplantar Keratoderma, Epidermolytic

  • Epidermolytic Palmoplantar Keratoderma

  • EPPK

  • Keratosis Palmaris Et Plantaris Familiaris

  • Tylosis

  • Keratosis Of Greither

  • Diffuse Nonepidermolytic Palmoplantar Keratoderma

  • Keratoderma, Palmoplantar, Epidermolytic

  • Unna-Thost Palmoplantar Keratoderma

  • Epidermolytic Palmoplantar Keratoderma Of Voerner

  • Ppke

  • Keratoderma, Epidermolytic Palmoplantar

  • Palmoplantar Keratoderma, Vorner Type

  • Hyperkeratosis, Localized Epidermolytic

  • Diffuse Erythrodermic Palmoplantar Keratoderma, Vörner Type

  • Epidermolytic Palmoplantar Keratoderma Of Vörner

  • Hyperkeratosis Palmoplantar Localized Epidermolytic

  • Diffuse Neppk

  • Ppk Diffusa Circumscripta

  • Thost-Unna Disease

  • Thost-Unna Palmoplantar Keratoderma

  • Diffuse Erythrodermic Palmoplantar Keratoderma, Voerner Type

  • Diffuse Erythrodermic Palmoplantar Keratoderma, Vorner Type

  • Epidermolytic Palmoplantar Keratoderma Of Vorner

  • Ehppk

  • Epidermolytic Unna-Thost Disease

  • Localized Epidermolytic Hyperkeratosis

  • Palmoplantar Keratoderma Vorner Type

  • Unilateral Palmoplantar Verrucous Nevus

  • UPVN

  • Keratoderma, Palmoplantar, Diffuse

  • Hyperkeratosis

  • Palmoplantar Keratoderma, Nonepidermolytic

  • Epidermolytic Palmoplantar Keratoderma Vorner Type

  • Type B Tylosis

  • Hyperkeratosis Of The Palms And Soles And Esophageal Papillomas

  • Type A Tylosis
Osteogenesis Imperfecta, Type Iv

  • Osteogenesis Imperfecta Type 4

  • Osteogenesis Imperfecta Type Iv

  • OI4

  • Oi, Type Iv

  • Osteogenesis Imperfecta With Normal Sclerae

  • Oi Type Iv

  • Oi Type 4

  • Osteogenesis Imperfecta With Normal Sclera

  • Common Variable Oi With Normal Sclerae

  • Osteogenesis Imperfecta 4

  • Oi-Iv
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07464 KRT77 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus KRT77 RGD RGD:1302968
Mus musculus KRT77 MGD MGI:3588209
Bos taurus KRT77 VGNC VGNC:50406
Felis catus KRT77 VGNC VGNC:84051
Others KRT77 NCBI