LHFPL3 - LHFPL tetraspan subfamily member 3 Gene

Also Known as LHFPL4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 375612

About LHFPL3

Cytogenetic location: 7q22.2-q22.3 Genomic coordinates (GRCh38): 7:104,328,603-104,908,561 (from NCBI)

This gene has 4 transcripts (splice variants), 266 orthologues and 6 paralogues. Biased expression in brain (RPKM 18.4) and lung (RPKM 1.0).

Summary

This gene is a member of the lipoma HMGIC fusion partner (LHFP) gene family, which is a subset of the superfamily of tetraspan transmembrane protein encoding genes. Mutations in one LHFP-like gene result in deafness in humans and mice, and a second LHFP-like gene is fused to a high-mobility group gene in a translocation-associated lipoma. A partial gene fragment named LHFPL4 corresponds to a portion of the first exon of this gene. [provided by RefSeq, Jul 2008]

LHFPL3 Products (2)

mRNA Protein Name
NM_001386065.1 NP_001372994.1 LHFPL tetraspan subfamily member 3 protein isoform 2
NM_199000.3 NP_945351.1 LHFPL tetraspan subfamily member 3 protein isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LHFPL3 Protein Structure

L_HMGIC_fpl

L_HMGIC_fpl: Lipoma HMGIC fusion partner-like protein (22 - 199)

  • 0
  • 100
  • 200
  • 222 a.a.
Protein Preferred Names Protein Names

LHFPL tetraspan subfamily member 3 protein

  • LHFP-like protein 3

LHFPL3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
LHFPL3 Q86UP9 RNF24 Homo sapiens Q9Y225-2
Validated Y2H
32296183
Intra
LHFPL3 Q86UP9 RNF24 Homo sapiens Q9Y225-2
Y2H Prey Pooling
32296183
Intra
LHFPL3 Q86UP9 RNF24 Homo sapiens Q9Y225-2
Y2H Array
32296183
Intra
LHFPL3 Q86UP9 PIGP Homo sapiens P57054
Y2H Array
32296183
Intra
LHFPL3 Q86UP9 PIGP Homo sapiens P57054
Y2H Prey Pooling
32296183
Intra
LHFPL3 Q86UP9 TNFSF14 Homo sapiens O43557
Y2H Array
32296183
Intra
LHFPL3 Q86UP9 TNFSF14 Homo sapiens O43557
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07627 LHFPL3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta LHFPL3 VGNC VGNC:81632
Felis catus LHFPL3 VGNC VGNC:102629
Rattus norvegicus LHFPL3 RGD RGD:1559727
Bos taurus LHFPL3 VGNC VGNC:30866
Mus musculus LHFPL3 MGD MGI:1925076
Others LHFPL3 NCBI