Prmt8 - protein arginine N-methyltransferase 8 Gene

Also Known as Hrmt1l3; Hrmt1l4

Species: Mus musculus

Gene Type: protein coding
Gene ID: 381813

About Prmt8

Chromosome 6: 127,665,974-127,746,435 reverse strand.GRCm39:CM000999.3

This gene has 1 transcript (splice variant), 281 orthologues, 7 paralogues and is associated with 9 phenotypes. Biased expression in cortex adult (RPKM 13.), frontal lobe adult (RPKM 11.1) and 6 other tissues.

Summary

Predicted to enable several functions, including S-adenosyl-L-methionine binding activity; protein homodimerization activity; and protein-arginine N-methyltransferase activity. Predicted to be involved in histone methylation; peptidyl-arginine methylation, to asymmetrical-dimethyl arginine; and protein homooligomerization. Predicted to act upstream of or within methylation. Predicted to be anchored component of the cytoplasmic side of the plasma membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including brain; genitourinary system; heart; and lung. Orthologous to human PRMT8 (protein arginine methyltransferase 8). [provided by Alliance of Genome Resources, Apr 2022]

Prmt8 Products (1)

mRNA Protein Name
NM_201371.2 NP_958759.2 protein arginine N-methyltransferase 8

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in regulation of modification of postsynaptic actin cytoskeleton IDA
IDA: Inferred from direct assay
32521269 MGI
involved in regulation of modification of postsynaptic actin cytoskeleton IEP
IEP: Inferred from expression pattern
32521269 MGI
involved in regulation of modification of postsynaptic actin cytoskeleton IMP
IMP: Inferred from mutant phenotype
32521269 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Prmt8 Protein Structure

AdoMet_MTases

AdoMet_MTases: cd02440 (114 - 214)

  • 0
  • 100
  • 200
  • 300
  • 394 a.a.
Protein Preferred Names Protein Names

protein arginine N-methyltransferase 8

  • HMT1 hnRNP methyltransferase-like 3

  • heterogeneous nuclear ribonucleoprotein methyltransferase-like 4

  • heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 4

  • protein arginine N-methyltransferase 4

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-128717A GSK3368715 dihydrochloride Inhibitor 99.96% Phase 1
HY-128717B GSK3368715 trihydrochloride Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (12)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-19615 MS023 Inhibitor 99.93% Unkown
HY-12970 EPZ020411 Inhibitor 98.07% Unkown
HY-12970A EPZ020411 hydrochloride Inhibitor 98.15% Unkown
HY-128717 GSK3368715 Inhibitor 99.41% Unkown
HY-19615B MS023 dihydrochloride Inhibitor 99.68% Unkown
HY-141877 MS4322 Degrader 99.14% Unkown
HY-100360 MS049 Inhibitor 98.0% Unkown
HY-141877B MS4322 (isomer) 99.87% Unkown
HY-146810 PRMT4-IN-1 Inhibitor / Unkown
HY-161334 CARM1-IN-4 Inhibitor / Unkown
HY-175821 PRMT1-IN-3 Inhibitor / Unkown
HY-186045 SKLB06489 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Prmt8 NCBI NCBI:56341