GRAPL - GRB2 related adaptor protein like Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 400581

About GRAPL

This gene has 5 transcripts (splice variants), 241 orthologues and 9 paralogues. Biased expression in spleen (RPKM 4.2), lymph node (RPKM 2.8) and 13 other tissues.

Summary

Predicted to enable receptor tyrosine kinase binding activity and signaling adaptor activity. Predicted to be involved in cell migration and signal transduction. [provided by Alliance of Genome Resources, Apr 2022]

GRAPL Products (2)

mRNA Protein Name
NM_001129778.3 NP_001123250.1 GRB2-related adapter protein-like isoform 1
NM_001353418.2 NP_001340347.1 GRB2-related adapter protein-like isoform 2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GRAPL Protein Structure

SH3_1

SH3_1: SH3 domain (4 - 49)

SH2

SH2: SH2 domain (60 - 103)

  • 0
  • 100
  • 118 a.a.
Protein Preferred Names Protein Names

GRB2-related adapter protein-like

  • GRB2-related adapter protein LOC400581

GRAPL Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
GRAPL Q8TC17 TCP11 Homo sapiens Q8WWU5-7
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05777 GRAPL Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus GRAPL MGD MGI:1918770