MATN2 - matrilin 2 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4147

About MATN2

Cytogenetic location: 8q22.1-q22.2 Genomic coordinates (GRCh38): 8:97,869,064-98,036,724 (from NCBI)

This gene has 18 transcripts (splice variants), 193 orthologues and 12 paralogues. Broad expression in thyroid (RPKM 133.8), placenta (RPKM 60.9) and 20 other tissues.

Summary

This gene encodes a member of the von Willebrand factor A domain containing protein family. This family of proteins is thought to be involved in the formation of filamentous networks in the extracellular matrices of various tissues. This protein contains five von Willebrand factor A domains. The specific function of this gene has not yet been determined. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

MATN2 Products (3)

mRNA Protein Name
NM_001317748.2 NP_001304677.1 matrilin-2 isoform c precursor
NM_002380.5 NP_002371.3 matrilin-2 isoform a precursor
NM_030583.4 NP_085072.2 matrilin-2 isoform b precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21078624 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MATN2 Protein Structure

VWA

VWA: von Willebrand factor type A domain (57 - 228)

FXa_inhibition

FXa_inhibition: Coagulation Factor Xa inhibitory site (242 - 277)

EGF_CA

EGF_CA: Calcium-binding EGF domain (283 - 318)

FXa_inhibition

FXa_inhibition: Coagulation Factor Xa inhibitory site (324 - 359)

FXa_inhibition

FXa_inhibition: Coagulation Factor Xa inhibitory site (365 - 400)

cEGF

cEGF: Complement Clr-like EGF-like (423 - 445)

FXa_inhibition

FXa_inhibition: Coagulation Factor Xa inhibitory site (570 - 605)

FXa_inhibition

FXa_inhibition: Coagulation Factor Xa inhibitory site (611 - 646)

VWA

VWA: von Willebrand factor type A domain (655 - 829)

Matrilin_ccoil

Matrilin_ccoil: Trimeric coiled-coil oligomerisation domain of matrilin (909 - 954)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 957 a.a.
Protein Preferred Names Protein Names

matrilin-2

  • testis tissue sperm-binding protein Li 94mP

MATN2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
MATN2 O00339 yopK Yersinia pestis O68704
Y2H Array
21911467
Intra
MATN2 O00339 ATXN7 Homo sapiens O15265
Pull Down
21078624
Intra
MATN2 O00339 ATXN7 Homo sapiens O15265
Y2H
21078624
Intra
MATN2 O00339 CACNA1A Homo sapiens O00555
Y2H
21078624
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Ovarian Endometrial Cancer

  • Endometrioid Neoplasm Of Ovary

  • Malignant Ovarian Endometrioid Tumor

  • Ovarian Endometrioid Neoplasm
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08171 MATN2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta MATN2 VGNC VGNC:74665
Canis familiaris MATN2 VGNC VGNC:43040
Felis catus MATN2 VGNC VGNC:68195
Mus musculus MATN2 MGD MGI:109613
Bos taurus MATN2 VGNC VGNC:31265
Rattus norvegicus MATN2 RGD RGD:1305353
Others MATN2 NCBI